Summary: Researchers are looking to a supercharged version of retinoic acid, which is derived from sprouts, to help develop new Alzheimer’s drugs.
Source: University of Aberdeen.
A supercharged version of the acid derived from our Christmas dinner veg is the basis of new research aimed at developing a new drug to treat Alzheimer’s disease.
Experts at the University of Aberdeen are working on a synthetic version of the beneficial acid created from vitamin A – a vitamin your body can get from eating a number of vegetables, including carrots and sprouts – which they hope may be used to treat neurological disorders.
In the body vitamin A is turned Into retinoic acid, which then interacts with specific receptors in the brain and plays a role in the development of the human central nervous system. It is particularly important for the eye and brain as the embryo is developing.
In the adult brain it is thought retinoic acid plays a different, more ‘focussed’ role and there are suggestions it could affect neural disorders, both degenerative and psychiatric.
Now, University of Aberdeen experts, in conjunction with the University of Durham and chemical development company High Force Research are set to begin a new two year, £250,000 project funded by the Biotechnology and Biological Sciences Research Council (BBSRC).
The researchers have designed synthetic versions of retinoic acid that interact with the body’s natural receptors in the brain in an even more powerful way than regular retinoic acid.
The team hope to progress the research to develop therapeutics– primarily for Alzheimer’s but potentially Parkinson’s disease and other neurodegenerative diseases.
Another unique aspect of the Aberdeen-led study is the method used to screen the new synthetic compounds making the process more efficient.
With the cost of drug discovery rising and the time to develop new drugs increasing, this new process is another important factor that contributed to the project being identified for further funding.
Professor Peter McCaffery, who is leading the project said: “We are basically trying to create a massively amplified version of what vitamin A already does for the body. By exploiting the natural consequences of retinoic acid by creating a synthetic alternative, we hope to be able to create a new therapeutic which could be used to help people with Alzheimer’s disease.
“There are other projects of a similar nature but they are focussed on different receptors and we are confident that our compound will prove to be more successful. Added to that, our unique screening process is an exciting innovation which should increase the efficiency of the process and could have implications beyond this particular project.”
Professor McCaffery will work alongside Dr Iain Greig and Professor Bettina Platt at the University of Aberdeen and Professor Andrew Whiting from the University of Durham.
Source: Euan Wemyss- University of Aberdeen
Image Source: NeuroscienceNews.com image is credited to University of Aberdeen.
Video Source: The video is credited to Life Sciences and Medicine, University of Aberdeen.
Original Research: Abstract for “A vitamin for the brain” by Kirsty D. Shearer, Patrick N. Stoney, Peter J. Morgan, Peter J. McCafferyemail in Trends in Neuroscience. Published online September 12 2016 doi:10.1016/j.tins.2012.08.005
A vitamin for the brain
In the central nervous system (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from its action in guiding embryonic development; as development comes to completion, retinoic acid signaling declines. However, it is increasingly recognized that this signaling mechanism does not disappear in the adult brain but becomes more regionally focused and takes on new roles. These functions are often tied to processes of neural plasticity whether in the hippocampus, through homeostatic neural plasticity, the olfactory bulb or the hypothalamus. The role of retinoic acid in the control of plastic processes has led to suggestions of its involvement in neural disorders, both degenerative and psychiatric. This review presents a snapshot of developments in these areas over recent years.
“A vitamin for the brain” by Kirsty D. Shearer, Patrick N. Stoney, Peter J. Morgan, Peter J. McCafferyemail in Trends in Neuroscience. Published online September 12 2016 doi:10.1016/j.tins.2012.08.005