Neuroscience News logo for mobile.
      Neuroscience News Logo

      Gut Microorganisms Affect Our Physiology

      FeaturedNeuroscienceOpen Neuroscience Articles
      ·December 29, 2016

      Summary: A new study reports the gut microbiota can modulate serotonin transporter activity.

      Source: University of Exeter.

      Researchers have found evidence that could shed new light on the complex community of trillions of microorganisms living in all our guts, and how they interact with our bodies

      Scientists at the University of Exeter Medical School and University of Zaragoza in Spain studied a protein known as TLR2, a critical detector of the microbiota found in the intestine. They found that it regulates levels of serotonin – a neurotransmitter which carries messages to the brain, and is also found in the gut, where it regulates our bowel routines.

      The research, carried out in cell cultures and verified in mice, provides strong evidence that microbiota can interfere with human physiology by modulating the serotonin transporter activity. Serotonin transporter is a target for numerous diseases and it seems that microbiota living in our guts is able to interfere with this transporter, controlling our serotonin levels.

      The finding, published in PLOS ONE, comes as scientists across the world are working to understand the complicated interactions between the “invisible world” of the microbiota in our bodies and the impact they have on our health and even our moods. Recently, scientists in California found evidence that the bacteria in the gut play a role in causing Parkinson’s Disease.

      It may also help explain how the microbiota in our guts affect our physiology. Inflammatory bowel disease is thought to be triggered when TLR2 is not functioning properly, but so far, the mechanisms behind this have not been fully understood. This study aimed to further this understanding, and was supported the Foundation for the Study of Inflammatory Bowel Diseases in Aragón (ARAINF), in Spain.

      Dr Eva Latorre, a postdoctoral researcher at the University of Exeter Medical School, said the new finding helped to further understanding in a fast-growing research area. She said: “This paper has concluded that the protein TLR2 alters the availability of serotonin, which is important in a range of conditions from depression to inflammatory bowel disease. It is early days in this research though. We need to understand much more about the relationship between the microbiota in our guts and how they interact, before we can hope to harness effective new treatments.”

      Image shows an intestinal tract.
      The research, carried out in cell cultures and verified in mice, provides strong evidence that microbiota can interfere with human physiology by modulating the serotonin transporter activity. Serotonin transporter is a target for numerous diseases and it seems that microbiota living in our guts is able to interfere with this transporter, controlling our serotonin levels. NeuroscienceNews image is for illustrative purposes only.

      The research team examined human cells in a model of the intestine in the laboratory, looking at how they express proteins and RNA – activities which regulate how they behave. They found that TLR2 controls serotonin transporter – obtaining the same result in studies on mice.

      Principal investigator of this study, Professor José E Mesonero, at the University of Zaragoza, said: “This paper opens our minds about the complex universe of this forgotten organ: the microbiome. We have concluded that TLR2 not only can detect microbiota, but also modulate serotonin transport, one of the crucial mechanism in neurological and inflammatory diseases. Much has to be yet studied, but this work can improve our understanding about the connection between gut and brain thought microbiota.”

      About this neuroscience research article

      Source: Louise Vennells – University of Exeter
      Image Source: NeuroscienceNews.com image is in the public domain.
      Original Research: Full open access research for “Intestinal serotonin transporter inhibition by Toll-like receptor 2 activation. A feedback modulation” by Eva Latorre, Elena Layunta, Laura Grasa, Marta Castro, Julián Pardo, Fernando Gomollón, Ana I. Alcalde, and José E. Mesonero in PLOS ONE. Published online December 29 2016 doi:10.1371/journal.pone.0169303

      Cite This NeuroscienceNews.com Article

      [cbtabs][cbtab title=”MLA”]University of Exeter “Gut Microorganisms Affect Our Physiology.” NeuroscienceNews. NeuroscienceNews, 29 December 2016.
      <https://neurosciencenews.com/physiology-gut-microorganism-5831/>.[/cbtab][cbtab title=”APA”]University of Exeter (2016, December 29). Gut Microorganisms Affect Our Physiology. NeuroscienceNew. Retrieved December 29, 2016 from https://neurosciencenews.com/physiology-gut-microorganism-5831/[/cbtab][cbtab title=”Chicago”]University of Exeter “Gut Microorganisms Affect Our Physiology.” https://neurosciencenews.com/physiology-gut-microorganism-5831/ (accessed December 29, 2016).[/cbtab][/cbtabs]


      Abstract

      Intestinal serotonin transporter inhibition by Toll-like receptor 2 activation. A feedback modulation

      TLR2 is a microbiota recognition receptor that has been described to contribute to intestinal homeostasis and to ameliorate inflammatory intestinal injury. In this context, serotonin (5-HT) has shown to be an essential intestinal physiological neuromodulator that is also involved in intestinal inflammatory diseases. Since the interaction between TLR2 activation and the intestinal serotoninergic system remains non-investigated, our main aim was to analyze the effect of TLR2 on intestinal serotonin transporter (SERT) activity and expression and the intracellular pathways involved. Caco-2/TC7 cells were used to analyze SERT and TLR2 molecular expression and SERT activity by measuring 5-HT uptake. The results showed that apical TLR2 activation inhibits SERT activity in Caco-2/TC7 cells mainly by reducing SERT protein level either in the plasma membrane, after short-term TLR2 activation or in both the plasma membrane and cell lysate, after long-term activation. cAMP/PKA pathway appears to mediate short-term inhibitory effect of TLR2 on SERT; however, p38 MAPK pathway has been shown to be involved in both short- and long-term TLR2 effect. Reciprocally, 5-HT long-term treatment yielded TLR2 down regulation in Caco-2/TC7 cells. Finally, results from in vivo showed an augmented intestinal SERT expression in mice Tlr2-/-, thus confirming our inhibitory effect of TLR2 on intestinal SERT in vitro. The present work infers that TLR2 may act in intestinal pathophysiology, not only by its inherent innate immune role, but also by regulating the intestinal serotoninergic system.

      “Intestinal serotonin transporter inhibition by Toll-like receptor 2 activation. A feedback modulation” by Eva Latorre, Elena Layunta, Laura Grasa, Marta Castro, Julián Pardo, Fernando Gomollón, Ana I. Alcalde, and José E. Mesonero in PLOS ONE. Published online December 29 2016 doi:10.1371/journal.pone.0169303

      Feel free to share this Neuroscience News.
      Join our Newsletter
      Thank you for subscribing.
      Something went wrong.
      I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )
      Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free.
      We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time.
      Tags
      Geneticsgut bacteriainflammationmicrobiomemicrobiotaneurobiologyneuroinflammationNeuroscienceOpen Accessopen scienceserotoninTLR2Toll like receptor 2University of Exeter
      ShareTweetShareShareSubmitEmail
      Neuroscience News
      Neuroscience News posts science research news from labs, universities, hospitals and news departments around the world. Science articles cover neuroscience, psychology, AI, robotics, neurology, brain cancer, mental health, machine learning, autism, Parkinson's, Alzheimer's, brain research, depression and other sciences.
      Related
      This shows a woman surrounded by a moon and hearts.

      Oxytocin Protects Mood During Sleep Loss

      This shows a brain and a syringe.

      Weekly Injection Could Revolutionize Parkinson’s Treatment

      This shows DNA.

      Gene Key to MS Immune Regulation Discovered

      Neuroscience News Footer Logo
      • Facebook
      • X
      • Instagram
      • YouTube
      • Linkedin

      Neuroscience News Sitemap
      Neuroscience Graduate and Undergraduate Programs
      Free Neuroscience MOOCs
      About
      Contact Us
      Privacy Policy
      Submit Neuroscience News
      Subscribe for Emails

      Neuroscience Research
      Psychology News
      Brain Cancer Research
      Alzheimer’s Disease
      Parkinson’s News
      Autism / ASD News
      Neurotechnology News
      Artificial Intelligence News
      Robotics News

      Search Neuroscience News

      Neuroscience News is an online science magazine offering free to read research articles about neuroscience, neurology, psychology, artificial intelligence, neurotechnology, robotics, deep learning, neurosurgery, mental health and more.

      Neuroscience News
      • Neuroscience
        • Featured
        • Neuroscience Videos
        • Neuro Web Stories
        • Open Access Neuroscience
        • Electrophysiology
        • Genetics
        • Neuroscience Programs
      • Neurology
        • Alzheimer’s Disease
        • Brain Research
        • Brain Cancer
        • Autism
        • Epilepsy
        • Traumatic Brain Injuries
        • Parkinson’s Disease
      • Psychology
        • Schizophrenia
        • Depression
        • Bipolar Disorder
        • Mental Health
      • AI
        • Neural Networks
        • Deep Learning
        • Machine Learning
      • Robotics
      • Neurotech
        • Brain Computer Interfaces
        • Neuroprosthetics
      • About
        • Neuroscience Newsletters
        • Submit Neuroscience News
        • Privacy Policy
        • Neuroscience News Sitemap
        • Contact Neuroscience News
        • Advertise on Neuroscience News
      Neuroscience News Small Logo
      • Neuroscience
        • Featured
        • Neuroscience Videos
        • Neuro Web Stories
        • Open Access Neuroscience
        • Electrophysiology
        • Genetics
        • Neuroscience Programs
      • Neurology
        • Alzheimer’s Disease
        • Brain Research
        • Brain Cancer
        • Autism
        • Epilepsy
        • Traumatic Brain Injuries
        • Parkinson’s Disease
      • Psychology
        • Schizophrenia
        • Depression
        • Bipolar Disorder
        • Mental Health
      • AI
        • Neural Networks
        • Deep Learning
        • Machine Learning
      • Robotics
      • Neurotech
        • Brain Computer Interfaces
        • Neuroprosthetics
      • About
        • Neuroscience Newsletters
        • Submit Neuroscience News
        • Privacy Policy
        • Neuroscience News Sitemap
        • Contact Neuroscience News
        • Advertise on Neuroscience News

      Categories

      • Artificial Intelligence
      • Auditory Neuroscience
      • Autism
      • Brain Cancer
      • Deep Learning
      • Electrophysiology
      • Events
      • Featured
      • Featured Articles
      • Genetics
      • Machine Learning
      • Most Popular
      • Neuroethics
      • Neurology
      • Neuroscience
      • Neuroscience Abstracts
      • Neuroscience Book Reviews
      • Neuroscience Business
      • Neuroscience Intros
      • Neuroscience News
      • Neuroscience News.com
      • Neuroscience Opinions
      • Neuroscience Videos
      • Neurotech
      • Open Neuroscience Articles
      • Pain
      • Psychology
      • Robotics
      • Sponsored Neuroscience News
      • Visual Neuroscience
      Neuroscience News LogoNeuroscience News
      This shows a woman surrounded by a moon and hearts.

      Oxytocin Protects Mood During Sleep Loss

      This shows a brain and a syringe.

      Weekly Injection Could Revolutionize Parkinson’s Treatment

      This shows DNA.

      Gene Key to MS Immune Regulation Discovered

      This shows a sad mom sitting by a crib.

      Maternal Depression Linked to Weaker Bonds

      Start typing to see results or hit ESC to close
      Neuroscience neurobiology brain research Psychology Neurology
      See all results

      Subscribe

      Neuroscience News Daily Emails
      Go to Appearance > Customize > Subscribe Pop-up to set this up.