Gut Bacteria Interferes with Metabolism of Parkinson’s Drug
Study provides first concrete examples of how the microbiome can interfere with a drug's intended path throughout the body.... Read More...
microbiota
High levels of rare gut bacteria may be linked to restless legs syndrome
Findings from a small sample study link small intestinal bacterial overgrowth (SIBO) to restless leg syndrome. ... Read More...
Antibiotic produced by the microbiome kills bacteria by disturbing energy metabolism
A synthetic version of a fibupeptide, which is naturally produced by the microbiome, may help in the fight against antibiotic-resistant bacteria. Lugdunin has been shown to be effective against MRSA. The findings could help in the creation of a new class of antibiotics to treat infections currently resistant to drugs on the market.... Read More...
Gut check: Researchers describe role of gut bacteria in drug response
Researchers have identified causal links between microbiota gene content and metabolic activity which impacts personal differences in drug metabolism. The findings help explain why some people don't respond to, or have adverse side effects from taking medications, while others don't.... Read More...
Gut bacteria’s connections to human health and disease
Study goes beyond evaluating the organisms in the microbiome, looking at the functions different bacteria may be performing.... Read More...
Gut bacteria influence autism-like behaviors in mice
Using germ-free mouse models, researchers transplanted fecal bacteria from children on the autism spectrum and neurotypical children. Mice who received the transplants from the ASD cohort began to exhibit autism-like behaviors, whereas the mice who received transplants from typically developing children did not. Additionally, the mice showed altered gene expression in their brains and differences in types of metabolites present. In particular, the ASD mice had lower levels of 5AV and taurine. Findings suggest gut microbiota regulates autism-like behaviors via the production of neuroactive metabolites, providing further evidence for the gut-brain axis connection to the pathology of autism.... Read More...
Research confirms gut-brain connection in autism
Genetic mutations, which occur in both the brain and gut, could be a main cause of autism. Using mouse models of ASD, researchers discovered the neuroligin-3 R451C mutation affects neural communication in the brain and causes dysfunction in the gut. The findings strengthen the gut-brain hypothesis of autism.... Read More...
Anxiety might be alleviated by regulating gut bacteria
A new meta-analysis study reports regulating intestinal microbiota is more than 50% effective at helping to reduce anxiety. Non-probiotic interventions were more effective than probiotic interventions at helping to relieve symptoms. ... Read More...
Bacteria in fermented food signal the human immune system, explaining health benefits
A metabolite produced by lactic acid bacteria binds to the third hydroxycarboxylic acid receptor (HCA), signalling the immune system. Researchers believe the receptor evolved to allow great apes to consume foods that were starting to decay. They suggest the receptor could mediate some beneficial and anti-inflammatory effects of lactic acid in humans, and could serve as a target to treat inflammatory diseases.... Read More...
Like A Lot of Things, Women’s Gut Microbiomes Appear to Mature Earlier than Men’s
Young women have higher gut bacteria diversity than males, study reports. ... Read More...
Antibiotic treatment alleviates Alzheimer’s disease symptoms in male mice
Study reports specific gut bacteria can influence the development of Alzheimer's disease. In mouse models, long term antibiotic treatment reduced inflammation and the formation of amyloid plaques. However, the reduction was only seen in males. Additionally, the antibiotic treatment altered the activation of microglia in the male mouse models.... Read More...
How stressed-out gut bacteria may trigger autoimmune response
Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.... Read More...