How chronic inflammation may drive down dopamine and motivation
Computational model sheds light on the impact chronic, low-grade inflammation has on the mesolimbic dopamine system and motivational impairments.... Read More...
neuroinflammation
Inflammation induces anhedonia in women but not men
Inflammation appears to reduce reward response in females. Reduced activity in the brain's reward system is a key component of anhedonia, the loss of enjoyment in activities, a core feature of depression. The findings may explain why depression is more prevalent in women than in men.... Read More...
Probiotic-derived molecule may suppress fatal brain inflammation
Capsular polysaccharide A (PSA), an envelope molecule, may help to boost the immune system and protect against potentially fatal neuroinflammation associated with Herpes Simplex Encephalitis (HSE). Mice given PSA survived exposure to a lethal herpes simplex viral infection, while those not treated with the probiotic did not, despite both groups being treated with a common antiviral used to treat HSE.... Read More...
How mutations lead to neurodegenerative disease
Genetic mutations which lead to abnormal RNA in regions of repeat DNA sequences set off anti-viral like inflammatory responses. This leads to apoptosis and ultimately trigger the onset of neurodegenerative diseases. ... Read More...
Detailed brain map uncovers hidden immune cells that may be involved in neurodegenerative disorders
Using mouse models, researchers have developed a comprehensive map of the brain's immune cells. The study found microglia in the choroid plexus showed a similar activation state as microglia that come into contact with Amyloid deposits. ... Read More...
Restoring brain function in mice with symptoms of Alzheimer’s disease
Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.... Read More...
New technique may improve detection and treatment of advanced brain cancer
Researchers discovered changes in thousands of genes induced by the tumor microenvironment. The study may help in identifying new biomarkers for the early detection, and subsequent treatment, of brain cancers.... Read More...
Microglia, immune cells of the central nervous system, shown to regulate neuroinflammation
In uveitis, microglia facilitates the entry of inflammatory immune cells into the retina, enabling the host immune responses to attack cells not normally recognized by the immune system.... Read More...
Non-invasive vagus nerve stimulation shows promise for treatment of rheumatoid arthritis
Non-invasive vagus nerve stimulation reduces inflammation and improves symptoms for those suffering from rheumatoid arthritis. The simulation technique helps inhibit the production of cytokines and reduces inflammatory response.... Read More...
This gene could play a major role in reducing brain swelling after stroke
The TRIM9 gene may help to resolve neuroinflammation and promote recovery following ischemic stroke.... Read More...
Inflammation linked to chemical imbalance in schizophrenia
Increased kynurenic acid production has been implicated in the pathology of schizophrenia. The findings provide a new target for cell-specific treatments that help reduce the production of kynurenic acid and reduce symptoms of schizophrenia.... Read More...
Could eating garlic reduce aging-related memory problems?
Eating garlic containing allyl sulfide may promote memory consolidation and improve cognition by restoring essential gut bacteria.... Read More...