FeaturedNeurologyNeurosciencePsychology·May 15, 2020The Potential of COVID-19 to Infect the BrainFrom losing the sense of taste or smell to developing an increased risk of stroke, researchers investigate both the known and potential long-term implications of COVID-19 infection in the brain. Read More
FeaturedNeurologyNeuroscience·May 11, 20203D brain-like tissue model links Alzheimer’s disease with herpesA 3D human tissue culture model demonstrated a possible causal relationship between Alzheimer's disease and herpes simplex virus 1 (HSV-1) infection. 40 Alzheimer's associated genes were over-expressed in the HSV-1 infected brain tissue, including genes associated with the production of amyloid-beta. Read More
FeaturedNeurologyNeuroscience·April 27, 2020Reducing early brain inflammation could slow Alzheimer’s progressionReducing neuroinflammation in the brain before cognitive impairment becomes apparent can help slow the progression of Alzheimer's disease. Read More
FeaturedGeneticsNeurologyNeuroscience·April 13, 2020Toxic cell atlas guides new therapies for neurodegenerationA new method called Tox-seq found only one sub-group of microglia caused oxidative stress. The gene expression signatures of this sub-group from a mouse model matched patterns observed in cells suspected of causing damage in progressive multiple sclerosis patients. The pattern of gene expression associated with oxidative stress in mouse cells included genes involved in coagulation. Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·April 9, 2020First in-human study of drug targeting brain inflammation supports further developmentMW189, a small molecule drug candidate, blocks abnormal inflammation in the brain which contributes to injury and disease induced neurological impairments. Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·March 17, 2020Inflammation in the brain linked to several forms of dementiaIn all three types of frontotemporal dementia, researchers found the more the inflammation in each part of the brain, the more harmful the build-up of junk proteins. Read More
FeaturedNeuroscienceOpen Neuroscience Articles·March 17, 2020Injury to the nose increases risk of bacteria entering the brainDamage to the nasal epithelium increases the risk of bacteria entering into the brain, potentially resulting in long-term health problems. Read More
FeaturedGeneticsNeurologyNeuroscience·February 24, 2020‘Resetting’ immune cells improves traumatic brain injury recoveryBy inhibiting a particular receptor microglia use to survive, researchers reduced neuroinflammation and prompted recovery following traumatic brain injury in mouse models. Read More
AutismFeaturedNeuroscienceOpen Neuroscience Articles·February 21, 2020Abnormally low levels of a key protein in brains of young men with autismMales on the autism spectrum have significantly lower levels of a protein in their brains' that plays a role in inflammation and metabolism. Read More
FeaturedNeuroscienceOpen Neuroscience Articles·February 11, 2020How the brain’s immune system could be harnessed to improve memoryAltering microglia in rats helped enhance their performance in memory tasks by up to 50%. The findings could help to develop new therapies that enhance memory function and prevent cognitive decline in humans. Read More
FeaturedNeurologyNeuroscienceneurotech·February 3, 2020Flickering light mobilizes brain chemistry that may fight Alzheimer’sExposure to light pulsing at 40 hertz causes the brain to release a surge of cytokines which activate microglia and reduces neuroinflammation. The findings could help with the development of new treatments to fight Alzheimer's disease. Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·January 14, 2020T. gondii cat parasite reduces general anxiety in infected mice, not just fear of feline predatorsMice infected with the Toxoplasma gondii parasite showed no selective reduction in fear of feline predators. Findings reveal chronic T. gondii infection reduces anxiety and risk-aversion while increasing curiosity and exploratory behaviors. Read More
