Treating inflammation with inflammation
Ter119, an inflammatory antibody, has the potential to treat inflammation caused by autoimmune diseases, according to the findings of a new rodent study.... Read More...
neuroinflammation
Is pollution linked to psychiatric disorders?
Poor air quality has been linked to higher rates of bipolar disorder and major depressive disorder. Exposure to air pollution during the first ten years of like is also associated with a more than two-fold increased risk of schizophrenia and personality disorders.... Read More...
Alzheimer’s drug reverses brain damage from adolescent alcohol exposure
Donepezil, a drug routinely administered to slow cognitive decline in Alzheimer's disease, shows promise in treating damage caused to the brain by adolescent alcohol exposure. The drug reverses neuroinflammation and neuron damage in rats exposed to alcohol during adolescence. ... Read More...
Immune system and mental health are connected
Researchers explore the link between the immune system and mental health disorders. Cytokines appear to play a critical role in the development and progression of mental illness. They question if administering prednisolone, a steroid that curbs inflammation, can have a beneficial effect on treating and preventing mental health problems.... Read More...
Raising eyebrows on neuroinflammation: Surprising role of ‘skin plumping’ hyaluronic acid
Hyaluronic acid, a substance naturally produced by the human body and a popular additive in cosmetics that boast plumper skin, may be a useful tool in treating neuroinflammation. ... Read More...
‘Crosstalk’ between genes promotes brain inflammation in Alzheimer’s
Findings could help in the development of treatments to prevent brain inflammation associated with Alzheimer's disease.... Read More...
Reducing brain inflammation could treat tinnitus and other hearing loss-related disorders
Rodent study reveals noise-induced hearing loss is associated with elevated expression of proinflammatory cytokines and microglia activation in the primary auditory cortex. Pharmacologically depleting microglia helps prevent tinnitus in mice with noise-induced hearing loss.... Read More...
How chronic inflammation may drive down dopamine and motivation
Computational model sheds light on the impact chronic, low-grade inflammation has on the mesolimbic dopamine system and motivational impairments.... Read More...
Inflammation induces anhedonia in women but not men
Inflammation appears to reduce reward response in females. Reduced activity in the brain's reward system is a key component of anhedonia, the loss of enjoyment in activities, a core feature of depression. The findings may explain why depression is more prevalent in women than in men.... Read More...
Probiotic-derived molecule may suppress fatal brain inflammation
Capsular polysaccharide A (PSA), an envelope molecule, may help to boost the immune system and protect against potentially fatal neuroinflammation associated with Herpes Simplex Encephalitis (HSE). Mice given PSA survived exposure to a lethal herpes simplex viral infection, while those not treated with the probiotic did not, despite both groups being treated with a common antiviral used to treat HSE.... Read More...
How mutations lead to neurodegenerative disease
Genetic mutations which lead to abnormal RNA in regions of repeat DNA sequences set off anti-viral like inflammatory responses. This leads to apoptosis and ultimately trigger the onset of neurodegenerative diseases. ... Read More...
Detailed brain map uncovers hidden immune cells that may be involved in neurodegenerative disorders
Using mouse models, researchers have developed a comprehensive map of the brain's immune cells. The study found microglia in the choroid plexus showed a similar activation state as microglia that come into contact with Amyloid deposits. ... Read More...