MW189, a small molecule drug candidate, blocks abnormal inflammation in the brain which contributes to injury and disease induced neurological impairments.
In all three types of frontotemporal dementia, researchers found the more the inflammation in each part of the brain, the more harmful the build-up of junk proteins.
Damage to the nasal epithelium increases the risk of bacteria entering into the brain, potentially resulting in long-term health problems.
Altering microglia in rats helped enhance their performance in memory tasks by up to 50%. The findings could help to develop new therapies that enhance memory function and prevent cognitive decline in humans.
Exposure to light pulsing at 40 hertz causes the brain to release a surge of cytokines which activate microglia and reduces neuroinflammation. The findings could help with the development of new treatments to fight Alzheimer's disease.
Mice infected with the Toxoplasma gondii parasite showed no selective reduction in fear of feline predators. Findings reveal chronic T. gondii infection reduces anxiety and risk-aversion while increasing curiosity and exploratory behaviors.
Older mice given anti-inflammatory medication were better able to learn new tasks and became almost as adept at learning as mice half their age.
Chronic stress during pregnancy increases neuroinflammation. The immune changes may create circumstances in the brain, which increase susceptibility to postnatal depression.