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neuroinflammation

·February 12, 2026·7 min read

Beyond the Blood-Brain Barrier: New “Smart Gate” Shielding the Brain

For decades, we believed we understood the fortifications protecting our most vital organ. But a team of Belgian researchers just proved that the brain has been hiding a secret 'smart gate.' By identifying a unique population of 'base barrier cells' within the choroid plexus, scientists have uncovered a dynamic secondary shield that dictates exactly what—and who—gets access to the brain’s inner sanctum. This discovery doesn't just rewrite anatomy textbooks; it reveals exactly how systemic infections might be 'leaking' into our central nervous system, triggering neuroinflammation and disease.

Featured Neurology Neuroscience

·October 8, 2025·9 min read

Human Brain-on-a-Chip Reveals How Inflammation Breaks the Mind

Researchers have developed brain-on-a-chip technology that uses human tissue to model how the brain’s protective barrier breaks down during inflammation and disease. The system replicates the blood-brain barrier, showing how cytokine storms and leaked blood proteins can trigger harmful changes in brain cells.

Featured Neurology Neuroscience

·October 6, 2025·4 min read

CBD Calms the Inflamed Alzheimer’s Brain

A new study reveals that cannabidiol (CBD) can significantly reduce neuroinflammation associated with Alzheimer’s disease. In experiments using an Alzheimer’s mouse model, researchers found that inhaled CBD lowered the activity of key genes driving inflammation and decreased harmful proinflammatory molecules in the brain.

Featured Neurology Neuroscience

·September 26, 2025·3 min read

DMT Shows Promise in Protecting the Brain After Stroke

New research shows that DMT, a natural psychoactive compound found in plants and the human brain, can protect against stroke damage in animal and cell models. Treatment with DMT reduced infarct size, brain swelling, and inflammation, while also repairing blood-brain barrier function.

Featured Neurology Neuroscience

·June 24, 2025·3 min read

PET Imaging Maps Brain Inflammation in Progressive Speech Disorder

A novel PET imaging study has identified unique patterns of neuroinflammation in patients with progressive apraxia of speech (PAOS), a rare disorder that impairs the brain’s ability to plan speech. Using TSPO PET scans, researchers found elevated inflammation in brain regions involved in movement and speech, particularly in patients who also showed signs of Parkinson-plus syndromes.

Featured Genetics Neurology Neuroscience

·June 24, 2025·5 min read

Rare Mutation Shields Brain from Alzheimer’s by Silencing Inflammation

A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against Alzheimer’s disease by suppressing inflammatory signaling in the brain’s immune cells. Researchers found that this mutation dampens the cGAS-STING pathway, a key innate immune mechanism that is abnormally activated in Alzheimer’s and other neurodegenerative disorders.

Featured Neurology Neuroscience

·June 24, 2025·3 min read

Neuroimaging Pinpoints Brain Inflammation

A newly developed PET radiotracer, ¹⁸F-PDE-1905, offers high-resolution imaging of neuroinflammation by targeting a key enzyme inside microglia, the brain’s immune cells. Unlike traditional tracers that target general downstream markers, this novel tracer hones in on PDE4B, a critical regulator of inflammatory signaling.

This shows the outline of a child and a brain.

Featured Neuroscience Psychology

·June 12, 2025·6 min read

Childhood Trauma Rewires the Brain Through Inflammation

Childhood trauma doesn't just leave psychological scars—it biologically reshapes the brain through chronic neuroinflammation and structural changes, increasing vulnerability to psychiatric disorders later in life. New research shows that early adversity can reprogram immune responses, altering lifelong mental health outcomes.

Featured Genetics Neurology Neuroscience

·June 2, 2025·6 min read

Blocking Brain Inflammation Molecule May Halt Alzheimer’s

A new study has uncovered a surprising culprit in the progression of Alzheimer’s disease: the immune molecule STING. Scientists found that STING, normally involved in defending the brain, becomes hyperactive with age, causing harmful inflammation and accelerating brain damage.

This shows the outline of a person and neurons.

Autism Featured Neuroscience Psychology

·May 19, 2025·4 min read

Inflammation Triggers Repetitive Behaviors in ASD and OCD

New research reveals that chronic brain inflammation can directly lead to repetitive behaviors, often seen in conditions like autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD). In mice with a mutated NLRP3 gene, inflammation activated microglia to release IL-1β, overstimulating NMDA glutamate receptors responsible for excitatory brain signals.

Featured Neurology Neuroscience

·May 15, 2025·4 min read

Long COVID Brain Fog Linked to Inflammation and Stress Markers

A new study comparing long COVID patients with fully recovered individuals has found that those with persistent cognitive symptoms, like brain fog, show higher brain inflammation and reduced capacity to handle stress. The study revealed lower levels of nerve growth factor and elevated inflammatory markers in the long COVID group.

Featured Neurology Neuroscience

·April 29, 2025·3 min read

New Biomarker Predicts MS Progression

Researchers have identified a new biomarker in multiple sclerosis (MS): the thickness of the inflammatory rim surrounding brain lesions predicts how quickly and severely the disease progresses. By combining PET imaging and post-mortem brain analysis, the study showed that thicker rims lead to more aggressive brain damage.

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neuroinflammation

Beyond the Blood-Brain Barrier: New “Smart Gate” Shielding the Brain

Human Brain-on-a-Chip Reveals How Inflammation Breaks the Mind

CBD Calms the Inflamed Alzheimer’s Brain

DMT Shows Promise in Protecting the Brain After Stroke

PET Imaging Maps Brain Inflammation in Progressive Speech Disorder

Rare Mutation Shields Brain from Alzheimer’s by Silencing Inflammation

Neuroimaging Pinpoints Brain Inflammation

Childhood Trauma Rewires the Brain Through Inflammation

Blocking Brain Inflammation Molecule May Halt Alzheimer’s

Inflammation Triggers Repetitive Behaviors in ASD and OCD

Long COVID Brain Fog Linked to Inflammation and Stress Markers

New Biomarker Predicts MS Progression

Individual Cone Cells Create Our Sharpest Sight

How Your Neighborhood and Nation Shape Your Brain’s Age

Alzheimer’s Risk Gene Shrinks Neurons

Noninvasive Stimulation “Talks” to the Brain’s Memory Center

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