SSRI antidepressants can make users less sensitive to rewards, resulting in emotional blunting many users experience. The findings provide new evidence for the role serotonin plays in reinforcement learning.
Taking SSRIs and having the "long-long" serotonin SERT genetic variant lowers SERT activity in the mitral valve, leading to degenerative mitral regurgitation, one of the most common heart valve diseases.
A newly identified serotonin pathway that originates from the median raphe nucleus acts in opposition to the reward/aversion pathway in the nearby dorsal raphe nucleus. The findings could pave the way for the development of new treatments for major depression, addiction, and other disorders associated with serotonin.
Researchers have developed a soft, implantable brain probe that can monitor serotonin and dopamine activity in real-time.
Mutations in the gene for the serotonin 2C receptor play a key role in obesity and dysfunctional behaviors in both human and animal models.
A new fluorescent sensor allows researchers to track the activity of serotonin and helps visualize serotonin dynamics in the brain.
Recent studies have suggested there is not enough evidence to support the serotonin hypothesis for depression. However, a new study shows direct evidence of disrupted serotonin release in the brains of those with depression.
Mice lacking a specific serotonin receptor unlearn fear faster than those with the receptor. The findings open the door to the development of new treatments for PTSD and other disorders associated with fear.
Excess fat from a mother's high-fat diet triggers immune cells to over-consume serotonin in the brains of developing males, leading to depression-like behaviors in the offspring.
Study identifies potential new drugs that can help treat depression and anxiety disorders without many of the adverse effects of other medications currently under evaluation.
Researchers shed light on how different SSRI antidepressants may work to help fight symptoms of depression in the brain.
Investigating how psychedelics such as psilocybin act on serotonin receptors, researchers shed new light on how the drugs affect consciousness and assist in treating a range of mental health disorders.
