SSRI's, ketamine, and tricyclic antidepressants all bind with TrkB. The findings challenge the roles serotonin and glutamate receptors play in the effects of antidepressant medications. Read More
LSD increases social behaviors by activating 5-HTPA serotonin receptors and AMPA receptors in the prefrontal cortex, and the mTORC1 protein. Activating all three factors promoted social interactions. The findings suggest supervised LSD microdosing may help alleviate some of the social problems associated with ASD and other mental health disorders that impact social behaviors. Read More
Artificial intelligence technology redesigned a bacterial protein that helps researchers track serotonin in the brain in real time. Read More
Researchers investigate how laughter improves both mental and physical well-being. Read More
Normal sleep in mice is reliant upon bacteria that help produce neurotransmitters, such as serotonin, in the gut. Read More
A new study reveals specific brain regions that individually promote patience through the action of serotonin. Read More
Study reveals a new role for serotonin in the development of the human neocortex. Serotonin acts cell-extrinsically as a growth factor for basal progenitors in the developing neocortex. Researchers report placenta-driven serotonin likely contributed to the evolutionary expansion of the neocortex in humans. Read More
People with OCD reported a reduction in the symptoms within four hours of smoking cannabis, a new study reports. Read More
STAT3 plays a crucial role in the serotonergic system as a molecular mediator for controlling emotional reactivity. The findings establish a link between the immune system, serotonergic transmission, and affective disorders such as depression. Read More
Researchers recorded alterations in levels of both dopamine and serotonin in the brain when people perform perception and decision making based tasks. Read More
p11, a protein implicated in serotonin function, affects the initial release of cortisol in mice by modulating the activity of specific neurons in the hypothalamus. Previous studies found people with depression lave lower levels of p11 in their brains. The findings could help in the development of new treatments for depression and stress. Read More
Researchers have uncovered the structure of psychedelic compounds when they actively bind to the 5-HT2A serotonin receptor on the surface of brain cells. The discovery could lead to the exploration of more precise compounds that offer the therapeutic effects of psychedelics for mental health disorders, but without the hallucinations. Read More
