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Summary: A new study reports children who exhibit excessive self control and have tendencies toward perfectionism are twice as likely to develop OCD by their teenage years. Researchers report perfectionist children often have smaller dorsal anterior cingulate cortex volume, an area of the brain linked to OCD.
Studying young children, researchers at Washington University School of Medicine in St. Louis found that kids who possess tendencies toward perfectionism and excessive self-control are twice as likely as other children to develop obsessive-compulsive disorder (OCD) by the time they reach their teens.
Further, MRI scans taken as part of the research revealed that the perfectionists often had smaller volumes of a brain structure previously linked to OCD.
The findings are published July 18 in the journal JAMA Psychiatry.
“Having a lot of self-control and striving for perfection often are considered by parents and society as good because they can eliminate mistakes, but excessive self-control and perfectionism raise a red flag,” said Kirsten E. Gilbert, PhD, the study’s first author and an instructor in child psychiatry at Washington University. “In adolescents and adults, these characteristics are associated with OCD and other disorders, such as anorexia and social anxiety. We’ve now been able to link this to OCD risk in children.”
OCD is a chronic mental health disorder that often involves uncontrollable, recurring thoughts, or obsessions — such as a fear of germs or a need to have things in perfect order — and behaviors that a person feels the urge to repeat over and over — such as hand-washing, compulsive counting or repeatedly checking on whether doors are locked.
Gilbert said it is important to identify the disorder as early as possible because the condition often is chronic and recurs throughout life. If very young children at risk can be identified, it may be possible to intervene earlier to prevent or at least lessen the intensity of obsessions and compulsions linked to OCD.
The researchers enrolled 292 children ages 4 and 5. Over the next 12 years, 35 kids went on to develop OCD. Among children the researchers determined were exercising excessive self-control and perfectionism, an OCD diagnosis was twice as likely as among those who didn’t care as much about performing a task absolutely correctly.
All of the children in the study were recruited more than a decade ago for a related study in which researchers evaluated young children for depression. The data for the new study was culled from the previous study’s videotaped interactions of children with a researcher.
“The experimenter would hand the child a blank sheet of paper and a green marker and simply say, ‘I need you to draw me a perfect, green circle,” Gilbert explained.
Drawing a perfect circle is difficult for almost anyone, but especially for young children. After a child would complete the drawing and show the circle to the researcher, the researcher would provide negative feedback, calling the circle “too small” or “too flat” and then would tell the child to try again. After 3 ½ minutes of negative feedback, the experimenter would admit to being too harsh, would praise the child and would tell him or her that everything was fine.
Gilbert and her colleagues evaluated the children’s behavior in videos of the attempts to draw perfect circles. The researchers rated the intensity of a child’s own performance monitoring as the youngster attempted to do a better job.
“Some kids were very self-critical,” Gilbert said. “The researcher would point out flaws, but the child was critical of the effort, too. That excessive perfectionism was the strongest predictor of OCD later on.”
Senior investigator Joan L. Luby, MD, the Samuel and Mae S. Ludwig Professor of Psychiatry and director of the university’s Early Emotional Development Program, said: “In its most severe forms, OCD is a highly disabling and intractable disorder. Therefore, this first identification of tangible risk behaviors in early childhood opens exciting new opportunities for the design of preventive interventions.”
As the children got older, 152 of them had a series of three MRI brain scans over the next 10 to 12 years. The researchers found that those who behaved like perfectionists during the circle task also had smaller volumes of a brain structure called the anterior cingulate cortex, an anatomical feature in the brain that previously has been linked to OCD in adults.
Another of the study’s senior authors, Deanna M. Barch, PhD, chair of Washington University’s Department of Psychological & Brain Sciences in Arts & Sciences, and the Gregory B. Couch Professor of Psychiatry at the School of Medicine, explained that one of the primary problems underlying the obsessive thoughts and compulsive behaviors in OCD is a deficit in cognitive control, particularly involving the anterior cingulate cortex.
Most treatments for OCD involve medications and psychotherapy. If untreated, the condition can be chronic and severe.
“One of my interests, ideally, is to create therapies geared toward prevention,” Gilbert said. “We also want to look at the role of parenting because if one of these kids has a parent who’s always saying, ‘That’s not good enough!’ you can see how this problem could spiral.”
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Funding: This work was supported by the National Institute of Mental Health at the National Institutes of Health (NIH), grant numbers R01 MH064769, R01 MH090786-60, K23 MH115074-01 and T32 MH100019.
Source: Jim Dryden – WUSTL Publisher: Organized by NeuroscienceNews.com. Image Source: NeuroscienceNews.com image is adapted from the WUSTL news release. Original Research: Open access research for “Associations of Observed Performance Monitoring During Preschool With Obsessive-Compulsive Disorder and Anterior Cingulate Cortex Volume Over 12 Years” by Kirsten E. Gilbert, PhD; Margot E. Barclay, BA; Rebecca Tillman, MS; Deanna M. Barch, PhD; and Joan L. Luby, MD in Brain Stimulation. Published July 18 2018. doi:10.1001/jamapsychiatry.2018.1805
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[cbtabs][cbtab title=”MLA”]WUSTL”Perfectionism in Young Children May Indicate OCD Risk.” NeuroscienceNews. NeuroscienceNews, 20 July 2018. <https://neurosciencenews.com/ocd-perfectionism-9587/>.[/cbtab][cbtab title=”APA”]WUSTL(2018, July 20). Perfectionism in Young Children May Indicate OCD Risk. NeuroscienceNews. Retrieved July 20, 2018 from https://neurosciencenews.com/ocd-perfectionism-9587/[/cbtab][cbtab title=”Chicago”]WUSTL”Perfectionism in Young Children May Indicate OCD Risk.” https://neurosciencenews.com/ocd-perfectionism-9587/ (accessed July 20, 2018).[/cbtab][/cbtabs]
Associations of Observed Performance Monitoring During Preschool With Obsessive-Compulsive Disorder and Anterior Cingulate Cortex Volume Over 12 Years
Importance Monitoring one’s performance is necessary for learning and adaptive behavior; however, heightened performance monitoring is a purported endophenotype of obsessive-compulsive disorder (OCD). The anterior cingulate cortex (ACC), a brain region implicated in the pathogenesis of OCD, is associated with performance monitoring. Whether performance monitoring early in development is an identifiable risk factor for OCD and whether early childhood performance monitoring is associated with later alterations in ACC volume are unknown.
Objective To determine whether an observed indicator of heightened performance monitoring during the preschool age is associated with later onset of OCD and altered dorsal ACC (dACC) volume through adolescence.
Design, Setting, and Participants This longitudinal observational cohort study was performed at an academic medical center as part of the Preschool Depression Study. A sample of 292 children oversampled for depression from September 22, 2003, through May 12, 2005, completed a performance-based observational task during which they received persistent negative evaluation. Blind raters behaviorally coded child performance monitoring. During the next 12 years, children completed annual diagnostic assessments; 133 completed the final behavioral follow-up and 152 contributed 1 to 3 magnetic resonance imaging scans. Follow-up was completed on August 14, 2017.
Main Outcomes and Measures Onset of DSM-5 diagnosis of OCD from baseline to the final behavioral assessment and whole-brain–adjusted dACC volume at the 3 waves of scanning.
Results Among the 292 preschool children who completed the baseline evaluation (51.4% boys; mean [SD] age, 4.5 [0.8] years), when controlling for demographic and clinical indicators, those who exhibited observed heightened performance monitoring were 2 times more likely to develop OCD (n = 35) during the next 12 years (odds ratio, 2.00; 95% CI, 1.06-3.78; P = .03). Multilevel modeling of dACC volume across the 3 scan waves (n = 152) demonstrated that heightened performance monitoring was associated with smaller right dACC volume (intercept estimate, −0.14; SE, 0.07; t = −2.17; P = .03).
Conclusions and Relevance An ecologically valid indicator of performance monitoring in early childhood was associated with onset of OCD and smaller dACC volumes in later childhood and adolescence. Early childhood observed performance monitoring is a readily observed risk factor of OCD that can be identified in preschool-aged children.
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