Gantenerumab, an investigational drug for Alzheimer's disease, reduced amyloid plaques and lowered tau levels in the brains of people with genetic risk factors for the neurodegenerative disorder.
Immune cells in the meninges come from bone marrow in the skull and migrate to the brain through special channels without passing through the blood. These immune cells help to guard the brain and spinal cord against inflammation and infection.
A new method, dubbed DREADDs, relies on gene therapy techniques to alter genes in target cells to change the cell's behavior. The method reduced anxious behaviors in monkey models of schizophrenia when combined with clozapine. Researchers say the method has the potential for use in humans to help reduce anxiety.
Administering the chemotherapy drug temozolomide to glioblastoma brain cancer patients in the morning may enhance the cancer-fighting effects. The study demonstrates the timing of chemotherapy could have a significant impact on treatment for glioblastoma patients.
Mouse study reveals elevated dopamine levels preceded hallucination-like events, and artificially boosting dopamine levels induced more hallucination-like events. The behavioral effects could be blocked by administering haloperidol, an antipsychotic which blocks dopamine. The study sheds light on potential new treatments for psychotic disorders marked by hallucinations.
An antibody called HAE-4 targets APOE and removes Alzheimer's related amyloid plaques in mouse models. The antibody improves blood vessel function in the brain without raising the risk of brain bleeds.
Study reveals a detailed map of gene proteins, infiltrating cells, and signaling pathways that play significant roles in the development and progression of glioblastoma brain cancer.
Immune cells in the meninges monitor fluid released from the brain. If the fluid contains signs of infection, disease, or damage, the immune cells initiate an immune response to tackle the problem.
Those with eczema who produce immunoglobulin E in response to environmental allergens are more likely to experience chronic and acute itching.