A group of neurons located in the basal ganglia appears to play a vital role in cognitive flexibility. Read More
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Comparing data from multiple neuroimaging studies, researchers found shared brain structural abnormalities between four psychiatric disorders, including schizophrenia and bipolar disorder. They also identified brain signatures unique to each condition. Read More
Targeted deep brain stimulation may help treat obsessive-compulsive disorder. Read More
The antipsychotic medication clozapine can trigger severe obsessive-compulsive symptoms (OCS) in patients. Adding aripiprazole can help manage clozapine-associated OCS. Read More
People with OCD have six times higher Immuno-moodulin (Imood) expression that those without the disorder. Blocking Imood with the aid of an antibody reduced OCD-like behaviors in mouse models within a couple of days following treatment. Read More
Those with obsessive-compulsive disorder (OCD) may place less trust in their previous experiences, increasing uncertainty, indecisiveness, and repetitive behaviors. Read More
Those with 22q11.2 deletion syndrome had significantly lower brain volume, as well as lower volumes in specific structures, including the thalamus, hippocampus, and amygdala. Read More
Exercise addiction is almost four times as common in those with eating disorders. Read More
The famous rubber hand illusion may help people with OCD overcome their condition without the stress of exposure therapy. Read More
Mice with dysfunctional Hoxb8-lineage microglia exhibited excessive overgrooming behaviors that resemble trichotillomania in humans. Female sex hormones also caused more severe OCD-like behaviors and increased anxiety in the mouse models. Read More
Researchers argue the existing categorical framework for mental illnesses needs to be revised, citing a substantial overlap between disorders, with most patients meeting the criteria for multiple disorders. Read More
Researchers have identified a comprehensive circuit mechanism that governs how emotional states can influence movement through connections in the basal ganglia. The mechanism represents a way in which emotional states relate to changes in action control in depression, anxiety, and OCD. Read More
