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neuroinflammation

Featured Neurology Open Neuroscience Articles

·August 7, 2020·4 min read

Key to Dialogue Between Brain Cells to Protect Against Stroke Discovered

DHA treatment reduced the size of the damaged brain area and initiated a repair mechanism in animal models of stroke. DHA affected the levels of MANF and TREM2, two proteins critical for communication between brain cells.

Featured Neurology Open Neuroscience Articles

·July 8, 2020·5 min read

Delirium, Rare Brain Inflammation and Stroke Linked to Covid-19

Coronavirus infection can lead to an array of neurological complications, including delirium, stroke, and a rare, often fatal neuroinflammatory condition called ADEM. The neurological complications did not always correlate with the severity of respiratory symptoms. In some patients, brain inflammation was likely caused by an immune response to COVID-19, suggesting the neurological damage may be a result of immune system activation rather than the virus itself.

Featured Neurology Neuroscience Psychology

·May 15, 2020·6 min read

The Potential of COVID-19 to Infect the Brain

From losing the sense of taste or smell to developing an increased risk of stroke, researchers investigate both the known and potential long-term implications of COVID-19 infection in the brain.

Featured Neurology Neuroscience

·May 11, 2020·4 min read

3D brain-like tissue model links Alzheimer’s disease with herpes

A 3D human tissue culture model demonstrated a possible causal relationship between Alzheimer's disease and herpes simplex virus 1 (HSV-1) infection. 40 Alzheimer's associated genes were over-expressed in the HSV-1 infected brain tissue, including genes associated with the production of amyloid-beta.

Featured Neurology Neuroscience

·April 27, 2020·2 min read

Reducing early brain inflammation could slow Alzheimer’s progression

Reducing neuroinflammation in the brain before cognitive impairment becomes apparent can help slow the progression of Alzheimer's disease.

Featured Genetics Neurology Neuroscience

·April 13, 2020·7 min read

Toxic cell atlas guides new therapies for neurodegeneration

A new method called Tox-seq found only one sub-group of microglia caused oxidative stress. The gene expression signatures of this sub-group from a mouse model matched patterns observed in cells suspected of causing damage in progressive multiple sclerosis patients. The pattern of gene expression associated with oxidative stress in mouse cells included genes involved in coagulation.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 9, 2020·3 min read

First in-human study of drug targeting brain inflammation supports further development

MW189, a small molecule drug candidate, blocks abnormal inflammation in the brain which contributes to injury and disease induced neurological impairments.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 17, 2020·5 min read

Inflammation in the brain linked to several forms of dementia

In all three types of frontotemporal dementia, researchers found the more the inflammation in each part of the brain, the more harmful the build-up of junk proteins.

Featured Neuroscience Open Neuroscience Articles

·March 17, 2020·3 min read

Injury to the nose increases risk of bacteria entering the brain

Damage to the nasal epithelium increases the risk of bacteria entering into the brain, potentially resulting in long-term health problems.

This shows brain slices from the research paper

Featured Genetics Neurology Neuroscience

·February 24, 2020·4 min read

‘Resetting’ immune cells improves traumatic brain injury recovery

By inhibiting a particular receptor microglia use to survive, researchers reduced neuroinflammation and prompted recovery following traumatic brain injury in mouse models.

This shows a drawing of a brain and a hand

Autism Featured Neuroscience Open Neuroscience Articles

·February 21, 2020·4 min read

Abnormally low levels of a key protein in brains of young men with autism

Males on the autism spectrum have significantly lower levels of a protein in their brains' that plays a role in inflammation and metabolism.

Featured Neuroscience Open Neuroscience Articles

·February 11, 2020·4 min read

How the brain’s immune system could be harnessed to improve memory

Altering microglia in rats helped enhance their performance in memory tasks by up to 50%. The findings could help to develop new therapies that enhance memory function and prevent cognitive decline in humans.

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