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Summary: Damage to the nasal epithelium increases the risk of bacteria entering into the brain, potentially resulting in long-term health problems.
Source: Griffith University
New research from Griffith University has shown that damage to the lining inside the nose increases the risk of bacteria sneaking into the brain via nerves, potentially causing long-term health issues.
Ph.D. candidate Heidi Walkden and her colleagues from the Menzies Health Institute Queensland, Institute for Glycomics and Griffith Institute for Drug Discovery, in collaboration with Queensland University of Technology, have discovered that damage to the nasal epithelium (lining of the nasal cavity) may increase the risk of the bacterium Burkholderia pseudomallei invading the brain.
This bacterium causes the disease melioidosis, endemic to northern Australia and South-East Asia. It has high mortality and can sometimes affect the central nervous system (brain and spinal cord).
“We have previously shown that, within 24 hours, B. pseudomallei can enter the central nervous system via peripheral nerves extending between the nasal cavity and the brain, bypassing the blood-brain barrier,” Ms Walkden said.
The new study shows that prior injury to the nasal lining—such as caused by colds, allergies and traumatic injuries—can increase the bacterial invasion of the olfactory nerve which mediates the sense of smell and leads directly from the nasal cavity into the brain. Infection of this nerve can strongly increase the risk for central nervous system infections.
Ms Walkden said their research showed that bacteria may sneak into our brain unnoticed, potentially causing serious long-term problems.
“Bacteria and viruses, and resultant neuroinflammation, may even contribute to neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases,”‘ she said.
“This research raises the question how often our brains are really exposed to infection. Because damage to the olfactory epithelium is common and the olfactory nerve normally regenerates quickly, such injuries are usually not noticed except when people dramatically lose their sense of smell.”
The research also showed that when the bacteria invade the olfactory nerve, peripheral nerve cells (glial cells), become infected and form abnormal giant cells. These cells are usually important defenders against bacteria, but in this case, they become infected and diseased.
“While the studies were conducted in mice, humans have the same nerves and can be infected by the same bacteria, so we believe the results are translatable to humans.
“The findings in this study may also in the future pave the way for new treatments, including preventative treatment, for central nervous system infections and the long-term problems that they cause.”
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Source: Griffith University Media Contacts: Press Office – Griffith University Image Source: The image is credited to Heidi Walkden et al.
Original Research: Open access “Burkholderia pseudomallei invades the olfactory nerve and bulb after epithelial injury in mice and causes the formation of multinucleated giant glial cells in vitro”. Heidi Walkden et al. PLOS Neglected Tropical Diseases doi:10.1371/journal.pntd.0008017.
Burkholderia pseudomallei invades the olfactory nerve and bulb after epithelial injury in mice and causes the formation of multinucleated giant glial cells in vitro
The infectious disease melioidosis is caused by the bacterium Burkholderia pseudomallei. Melioidosis is characterised by high mortality and morbidity and can involve the central nervous system (CNS). We have previously discovered that B. pseudomallei can infect the CNS via the olfactory and trigeminal nerves in mice. We have shown that the nerve path is dependent on mouse strain, with outbred mice showing resistance to olfactory nerve infection. Damage to the nasal epithelium by environmental factors is common, and we hypothesised that injury to the olfactory epithelium may increase the vulnerability of the olfactory nerve to microbial insult. We therefore investigated this, using outbred mice that were intranasally inoculated with B. pseudomallei, with or without methimazole-induced injury to the olfactory neuroepithelium. Methimazole-mediated injury resulted in increased B. pseudomallei invasion of the olfactory epithelium, and only in pre-injured animals were bacteria found in the olfactory nerve and bulb. In vitro assays demonstrated that B. pseudomallei readily infected glial cells isolated from the olfactory and trigeminal nerves (olfactory ensheathing cells and trigeminal Schwann cells, respectively). Bacteria were degraded by some cells but persisted in other cells, which led to the formation of multinucleated giant cells (MNGCs), with olfactory ensheathing cells less likely to form MNGCs than Schwann cells. Double Cap mutant bacteria, lacking the protein BimA, did not form MNGCs. These data suggest that injuries to the olfactory epithelium expose the primary olfactory nervous system to bacterial invasion, which can then result in CNS infection with potential pathogenic consequences for the glial cells.
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