A new small scale study reveals the antidepressant fluvoxamine may be a new tool in the fight against COVID-19. Researchers report fluvoxamine reduced the severity of coronavirus symptoms and hospitalizations. Read More
Altered microRNA levels in a person's saliva can help determine if they have experienced a recent concussion. The new saliva test is a cheap and non-invasive method for the identification of concussion. Read More
Placebos reduce biomarkers in the brain of emotional distress, even when a patient knows they are taking one. Read More
Famotidine (Pepcid AC), an over-the-counter medication used to treat indigestion, shows promise as a potential treatment for COVID-19. Read More
Treating coronavirus patients with alpha-blockers may help prevent the cytokine storm associated with severe COVID-19 infection. Alpha-blockers interfere with the cell signaling that triggers cytokine storms. Mice with bacterial infections that were treated with alpha-blockers experienced reduced cytokine storms and decreased death rates. Read More
Coronavirus patients treated with chloroquine or hydroxychloroquine are significantly more likely to experience ventricular arrhythmias than those who were treated with other medications. The study also revealed that out of 100,000 COVID-19 patients who were hospitalized, the 15,000 who received hydroxychloroquine were more likely to have worse health outcomes than those treated with other drugs. Read More
Interferon-a2b an antiviral treatment shows promise in helping to speed up the recovery of patients with severe COVID-19 infections. IFN-a2b improves viral clearance and decreases the levels of inflammatory markers in coronavirus patients. Read More
Researchers find no beneficial evidence to support the use of chloroquine or hydroxychloroquine, either used alone or in combination with azithromycin, for the treatment of COVID-19. Read More
Anakinra, a clinically approved anti-inflammatory used to treat rheumatoid arthritis, improves respiratory function in patients with severe COVID-19 infection. Read More
An aerosolized version of tissue plasminogen activator (tPA), a clot-busing drug commonly used for the treatment of stroke patients, could target blood clots that form as a result of severe coronavirus infection. Read More
UCSD has launched a Phase III clinical trial to assess whether tocilizumab (Actemra), a drug commonly prescribed for rheumatoid arthritis and other inflammatory disorders, has therapeutic value for those at risk of developing severe COVID-19 infection. The drug is a monoclonal antibody-based therapy that blocks receptors for interleukin-6, a cytokine that triggers inflammation as an early immune response to coronavirus. Blocking IL-6 could prevent the risk of the COVID-19 associated cytokine storm many with severe infection experience. Read More
A new mathematical model examined the immune response in patients with coronavirus. The findings suggest adaptive immune response may kick in before target immune cells are depleted, slowing the infection. The interaction of the innate and adaptive immune response may explain why some with coronavirus experience a second wave infection, appearing to get better before the symptoms return and get worse. Other studies have shown those who received immunosuppressants at the start of infection had a better clinical outcome than those who did not. Read More
