FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·April 14, 2022·5 min readKey Signaling Pathway in Immune Cells Could Be New Alzheimer’s TargetTau-tangles trigger the inflammatory activation of microglia via the NF-κB pathway. Inhibiting the microglia NF-κB signaling pulled the immune cells out of their inflammatory state and reversed learning and memory problems in tau-based Alzheimer's mouse models.Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·April 8, 2022·4 min readDepressive Disorders Can Lead to Changes in Immune CellsResearchers identified a link between major depressive disorder and mechanical alterations in blood cells.Read More
FeaturedNeurosciencePsychology·March 29, 2022·3 min readStudy Links Early Life Adversity, Microglia Dysfunction, to Aberrant Adult Stress Responses, Mental IllnessMicroglia dysfunction in those who experienced early life adversity prompts an aberrant stress response during adulthood that may be linked to mental illness.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·March 23, 2022·4 min readHow TREM2 Gene Mutation in Brain Microglia Immune Cells Can Increase Alzheimer’s RiskA molecular process caused by the TREM2 gene mutation in the brain's microglia increases the risk of Alzheimer's disease, a new study reports.Read More
FeaturedNeurologyNeuroscience·March 23, 2022·3 min readIntake of FDA-Approved Drug Modulates Disease Progression in Alzheimer’s ModelNiaspan, an FDA-approved drug, limits disease progression in lab models of Alzheimer's disease.Read More
FeaturedNeuroscience·March 7, 2022·2 min readUncovering How Immune Cells Nurture Brain ConnectionsA new study in mice finds microglia help neurons grow synapses critical for cognitive function.Read More
FeaturedNeuroscience·February 2, 2022·5 min readMechanism Behind Loss of Smell With COVID-19 RevealedInfection with the SARS_CoV-2 virus causes dials down the action of olfactory receptors, resulting in smell loss associated with COVID-19.Read More
FeaturedGeneticsNeurologyNeuroscience·January 9, 2022·3 min readResearch Clears up How Brain ‘Cleaners’ Fail in ALSFindings point to microglial TREM2 as a potential target for the treatment of ALS.Read More
FeaturedGeneticsNeuroscience·December 30, 2021·3 min readMicroglial Methylation Landscape in Human BrainMicroglia showed DNA methylation profiles that were distinct from other cells in the central nervous system.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·December 16, 2021·4 min readParkinson’s Disease Mutation Misdirects Iron in the BrainFindings reveal a common Parkinson's disease genetic mutation drives mislocalization of iron in activated microglia.Read More
FeaturedNeurologyNeuroscience·December 2, 2021·5 min readImmune Cells in the Brain Play Key Role in Relationship Between Gut Microbes and Amyloid Beta DepositsMicroglia, a key immune cell in the brain, appears to mediate the relationship between the gut microbiome and amyloid-beta deposits in male mouse models of Alzheimer's disease.Read More
FeaturedGeneticsNeurologyNeuroscience·December 1, 2021·4 min readTargeting the Brain’s Immune Cells May Help Prevent Alzheimer’s DiseaseA drug currently being tested in cancer clinical trials appears to prevent dysfunction in an immune cell signaling pathway associated with Alzheimer's disease. Blocking the pathway could prevent Alzheimer's from developing and slow the progression of symptoms for those who already have the disease.Read More
