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·December 16, 2021·4 min read

Parkinson’s Disease Mutation Misdirects Iron in the Brain

Findings reveal a common Parkinson's disease genetic mutation drives mislocalization of iron in activated microglia.

This shows microglia in the brain of alzheimer's mouse models

Featured Neurology Neuroscience

·December 2, 2021·5 min read

Immune Cells in the Brain Play Key Role in Relationship Between Gut Microbes and Amyloid Beta Deposits

Microglia, a key immune cell in the brain, appears to mediate the relationship between the gut microbiome and amyloid-beta deposits in male mouse models of Alzheimer's disease.

This shows single cell RNA sequencing of the microglia response in a mouse model of Alzheimer's

Featured Genetics Neurology Neuroscience

·December 1, 2021·4 min read

Targeting the Brain’s Immune Cells May Help Prevent Alzheimer’s Disease

A drug currently being tested in cancer clinical trials appears to prevent dysfunction in an immune cell signaling pathway associated with Alzheimer's disease. Blocking the pathway could prevent Alzheimer's from developing and slow the progression of symptoms for those who already have the disease.

Featured Neurology Neuroscience

·November 28, 2021·5 min read

Exercise May Reduce Brain Inflammation, Reducing the Risk of Alzheimer’s

Physical activity appears to reduce microglial activation and improve cognition in the aging human brain, researchers report.

Featured Neuroscience

·November 16, 2021·4 min read

Neuroimmune Interactions and Brain Plasticity

Researchers examine how neuroimmune interactions promote brain plasticity and shed new light on how neuroimmune activity may have implications for a range of disorders, including neurological changes experienced by COVID-19 survivors.

Featured Genetics Neurology Neuroscience

·November 5, 2021·4 min read

The Role of Gene Associated With Alzheimer’s Disease in Brain’s Immune Cells

Deleting ABI3, a gene associated with Alzheimer's disease, significantly increased amyloid-beta accumulation in the brain and decreased the amount of microglia around amyloid-plaques, researchers report.

Featured Neurology Neuroscience Open Neuroscience Articles

·October 16, 2021·4 min read

Discovery of New Role for the Brain’s Immune Cells Could Have Alzheimer’s Implications

Study reveals microglia play an important role in the maintenance of blood delivery to the brain. The findings may prove important to the study and treatment of cognitive decline, dementia, and stroke.

Featured Neurology Neuroscience

·October 13, 2021·3 min read

In Neurodegenerative Diseases, Brain Immune Cells Have a Ravenous Appetite for Sugar

In the early stages of neurodegenerative diseases, microglia consume glucose to a greater extent than previously believed. The findings may serve as a new biomarker for a range of neurodegenerative disorders.

Featured Neurology Neuroscience

·September 22, 2021·4 min read

Immune Cells in the Brain Share the Work

Microglia immune cells can join together to form networks when needed, a new study reports. However, certain mutations associated with Parkinson's disease can impair this process.

Featured Neurology Neuroscience

·September 10, 2021·5 min read

Researchers Build a Cellular Blueprint of Multiple Sclerosis Lesions

Analyzing the gene activity of 66,000 cells from human brain tissue, researchers generated a comprehensive map of cell types associated with brain lesions in multiple sclerosis, and their gene expression patterns and interactions.

Featured Genetics Neuroscience

·August 15, 2021·4 min read

Brain Gene Expression Patterns Altered by Chronic Opioid Use

Opioid use disorder affects genes associated with proinflammatory immune molecule encoding and genes associated with remodeling the extracellular matrix, suggesting the connection between neurons may be altered as a result of opioid use. Additionally, those with OUD have higher levels of microglia in the brain.