Changes in microglia underlie depressive symptoms brought on by exposure to chronic stress, a new study reports.
Reducing the expression of the protein TOM1 in mouse models of Alzheimer's disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects. Findings suggest a new therapeutic target for treating dementia.
Mice with dysfunctional Hoxb8-lineage microglia exhibited excessive overgrooming behaviors that resemble trichotillomania in humans. Female sex hormones also caused more severe OCD-like behaviors and increased anxiety in the mouse models.
Microglia plays crucial roles both in healthy and diseased brains, a new study reports.
Researchers have developed a new technique to measure levels of amyloid beta in the brain. They have also discovered new insights into why mutations of the TREM2 gene increases the risk of developing Alzheimer's disease.
HIV infection leads to increased EIF2 signaling in microglia, astrocytes, and neurons. Study reveals how HIV infection and some antiretrovirals affect cognition and the central nervous system.
Acute inflammation of the anterior cerebellum resulted in depression-like symptoms in rodent models. Suppressing microglia helped reduce hyperexcitability and symptoms of depression.
Exposure to allergic inflammation, while in utero, increased mast cell and microglia activation, leading to masculinization of dendritic spine density in the preoptic area of females. During adulthood, females exposed to allergic inflammation showed an increase in more masculine behaviors.