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microglia

·June 3, 2021·2 min read

Secondary Infections Inflame the Brain, Worsening Cognition in Alzheimer’s Disease

Secondary infections and novel inflammatory events, even ones that occur external to the brain, amplify the brain's immune response and detrimentally impact cognition in mouse models of Alzheimer's disease.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·May 21, 2021·4 min read

Gene Signature for Plaque-Eating Microglia in Alzheimer’s Disease Discovered

Study identifies gene expression signatures that underlie microglia associated with amyloid plaque phagocytosis.

Featured Neurology Neuroscience

·May 16, 2021·4 min read

Anesthetic May Affect Tau Spread in the Brain to Promote Alzheimer’s Disease Pathology

Sevoflurane, an anesthetic, causes tau to leave neurons and enter microglia. This stimulates the production of interleukin-6, leading to inflammation and cognitive impairment.

This shows AB plaques surrounded by microglia

Featured Genetics Neurology Neuroscience

·April 16, 2021·5 min read

Some Alzheimer’s Plaques May Be Protective, Not Destructive

Microglia creates dense-core plaques which help to clear away more wispy plaques from neurons, preventing cell death. Findings suggest the dense-core plaques play a defensive role in protecting the brain from the ravages of neurodegenerative diseases, such as Alzheimer's.

Featured Neurology Neuroscience

·March 2, 2021·3 min read

Potential Drug for Alzheimer’s Disease Prevention Found Safe and Effective in Animals

A new drug modulates, rather than inhibits, a key enzyme implicated in the formation of Alzheimer's related plaques.

This shows different slides and angles of the brainstem

Auditory Neuroscience Featured Neuroscience

·February 8, 2021·3 min read

Auditory Brainstem Pathways Do Not Develop Properly Without Microglia

Microglia are essential for pruning away extra neural connections in the development of the auditory brainstem.

Featured Neuroscience Psychology

·January 25, 2021·4 min read

Immune Cells in the Brain Are Behind the Depression Experienced in Inflammation

Microglia appear to play a key role in inflammation-associated depression.

Featured Genetics Neurology Neuroscience

·December 30, 2020·4 min read

Mutations Associated With Early Onset Dementia Discovered

Disruptions in circulating white blood cells may be a key driver in ALSP, a rare form of early-onset dementia.

Featured Neuroscience Psychology

·December 28, 2020·7 min read

Maternal Immune Activation Induces Sustained Changes in Fetal Microglia Motility

Changes in fetal microglia caused as a result of maternal inflammation could contribute to the development of schizophrenia, autism, and other psychiatric or developmental disorders.

Featured Neuroscience

·December 28, 2020·4 min read

Astrocytes Eat Connections to Maintain Plasticity in Adult Brains

Astrocytes, not microglia, are responsible for constantly eliminating unnecessary and excessive adult synaptic connections in response to brain activity.