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ketamine

·September 29, 2020·5 min read

Computer Model Explains Altered Decision Making in Schizophrenia

Summary: An artificial neural network has identified a potential mechanism for the impaired decision-making often seen in schizophrenia patients, which involves the reduced activity of NMDA receptors.

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·September 16, 2020·6 min read

Brain Circuitry Underlying Dissociative Experiences Identified

Researchers have identified a key neural circuit that plays a role in dissociation, a phenomenon in which people can feel disconnected from their bodies and reality.

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·June 11, 2020·5 min read

High doses of ketamine can temporarily switch off the brain

Higher doses of ketamine administered to sheep completely reduced brain activity for a short period. Researchers report as the drug wore off and consciousness was regained, the animals' brain activity switched between high and low-frequency oscillations. The timing of the brain activity corresponds to the time human users report experiencing feelings that their brain 'disconnected' from their bodies after ketamine use.

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·June 5, 2020·3 min read

NMDA receptors may link psychosis and sleep deficits

NMDA receptor hypofunction is involved in the reduction of sleep spindles and delta oscillations, which appear in the brain during deep natural sleep. Findings confirm the role NMDA receptors play in sleep disorders that accompany psychotic states.

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·June 1, 2020·4 min read

How ketamine combats depression

Ketamine increases the number of serotonin 1B receptors. Ketamine binds to serotonin 1B receptors, reducing the release of serotonin and increasing the release of dopamine.

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·April 26, 2020·4 min read

Effects of rapid-acting antidepressant ketamine consolidated in sleep?

Brain connections strengthened with treatment from fast-acting antidepressants, such as ketamine, are consolidated during deep sleep. Researchers propose rapid antidepressant treatments share the ability to regulate both synaptic potentiation and homeostatic mechanisms, which may contribute to how the brain reorganizes its activity to defeat depression.

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·March 11, 2020·2 min read

JNK protein triggers neurons to withdraw their synapses when stressed

Using optogenetics to inhibit the JNK protein prevented synapses from shrinking in response to stress.

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·November 26, 2019·5 min read

One shot of ketamine could reduce problem drinking

A single shot of ketamine administered to heavy drinkers following reactivation of their drinking memories led to a rapid decrease in the urge to drink. The effect lasted for over nine months.

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·November 18, 2019·4 min read

Side effects mild and brief with single antidepressant dose of intravenous ketamine

The side effects of administering ketamine to treat major depressive disorder are mild and persist for no longer than four hours, researchers report. Most of the side effects peaked within an hour of treatment, and many patients reported the effects as being significantly reduced two hours post ketamine administration.

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·November 18, 2019·3 min read

Ketamine reduces drinking in male rats, but not females

Ketamine reduced alcohol intake in male rat models of alcohol use disorder but increased the desire for alcohol in low-consumption females.

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·October 21, 2019·2 min read

One in three pain patients suffer side effects after ketamine infusion therapy

35% of patients who used ketamine to manage pain reported significant side effects ranging from hallucination, out-of-body experiences, visual disturbances, and urinary dysfunction. 20% of the side effects were linked directly to ketamine, and 15% associated with ketamine in combination with other drugs.

Featured Neuroscience Psychology

·September 1, 2019·5 min read

Psychedelic drugs: would you accept a prescription? It depends if you’ve tried them before

Numerous studies have linked controlled psychedelics to improvements in mental health conditions such as depression and PTSD. In March, the FDA approved Esketamine as a treatment for depression. However, with much stigma surrounding psychedelics, researchers question how many patients would take psychedelic medications if prescribed to them. According to a new study, 40% of people with no experience of psychedelics would be unlikely to take the prescription due to fears of 'brain damage' or a 'bad trip'.

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