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ketamine

·August 6, 2012·8 min read

Brain Signal IDs Responders to Fast-Acting Antidepressants

Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant like ketamine. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say NIH researchers.

Featured Neurology

·October 3, 2012·3 min read

Drug Reverses Abnormal Brain Function in Rett Syndrome Mice

in a mouse model of Rett syndrome, researchers were able to reverse abnormalities in brain activity and improve neurological function by treating animals with an FDA-approved anesthesia drug, ketamine.

The image shows neurons in a subsection of the adult rat hippocampus. The caption best describes the image.

Electrophysiology Featured

·May 30, 2013·4 min read

Ketamine Cousin Rapidly Lifts Depression Without Side Effects

A new study funded by the NIMH suggests GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the negative side effects of the well known street drug.

The image shows three different images of synaptic connections. The caption best describes the image.

Featured Genetics Psychology

·April 14, 2014·2 min read

New Finding Suggests a Way to Block Stress Damage

The gene REDD1 enables stress to damage neurons and cause depressive behavior, a new study reports.

This image shows a PET scan with changes in the dorsal anterior cingulate cortex.

Featured Open Neuroscience Articles Psychology

·October 20, 2014·4 min read

Rapid Agent Restores Pleasure Seeking Ahead of Other Antidepressant Action

Treatment resistant bipolar disorder patients experienced a reversal of a key symptom 40 minutes after a single infusion of ketamine, a new study reports.

This is the outline of a woman. Inside here head is an illustration of neurons.

Featured Psychology

·July 31, 2015·4 min read

Over-Active Glutamate Receptor Gene in Females with Depression

According to a new study, postmortem brain tissue from females who suffered from depression had abnormally high expression levels of a number of genes which regulate the glutamate system.

Featured Psychology

·December 21, 2015·3 min read

Brain Circuits Involved in Ketamine’s Antidepressant Effect Identified

New understanding about ketamine's antidepressant effect could lead to the development of new, safer and quicker ways to treat depression.

Featured Psychology

·January 12, 2016·3 min read

Compound Delivers Antidepressant Effect Within Hours

Researchers report those addicted to cocaine may have difficulty controlling their addiction because of a 'back door' into the brain that circumvents their self control.

Featured Open Neuroscience Articles Psychology

·January 13, 2016·4 min read

Inflammation Connected to Elevated Glutamate Could Guide Depression Treatments

A new study reports on which patients may respond best to depression treatments that target glutamate.

Featured Psychology

·February 1, 2016·3 min read

Treating Depression in Alcoholics

Researchers offer hope to alcoholics who find it hard to remain sober due to depression.

Image shows the chemical structure of AMPA.

Featured Neuroscience Videos Psychology

·May 4, 2016·6 min read

Ketamine Lifts Depression via a Byproduct of Its Metabolism

A metabolite created as the body breaks down ketamine could hold the key to understanding its antidepressant action, a new study reports.

Featured Psychology

·May 10, 2016·6 min read

Intravenous Ketamine May Rapidly Reduce Suicidal Thinking in Depressed Patients: Small Study

Repeat intravenous treatment with low doses of the anesthetic drug ketamine quickly reduced suicidal thoughts in a small group of patients with treatment-resistant depression, a new study reports.

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