Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant like ketamine. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say NIH researchers.
in a mouse model of Rett syndrome, researchers were able to reverse abnormalities in brain activity and improve neurological function by treating animals with an FDA-approved anesthesia drug, ketamine.
A new study funded by the NIMH suggests GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the negative side effects of the well known street drug.
Treatment resistant bipolar disorder patients experienced a reversal of a key symptom 40 minutes after a single infusion of ketamine, a new study reports.
According to a new study, postmortem brain tissue from females who suffered from depression had abnormally high expression levels of a number of genes which regulate the glutamate system.
New understanding about ketamine's antidepressant effect could lead to the development of new, safer and quicker ways to treat depression.
Researchers report those addicted to cocaine may have difficulty controlling their addiction because of a 'back door' into the brain that circumvents their self control.
A new study reports on which patients may respond best to depression treatments that target glutamate.
A metabolite created as the body breaks down ketamine could hold the key to understanding its antidepressant action, a new study reports.
Repeat intravenous treatment with low doses of the anesthetic drug ketamine quickly reduced suicidal thoughts in a small group of patients with treatment-resistant depression, a new study reports.