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autophagy

·December 2, 2024·6 min read

Ketone Bodies Clear Damaged Proteins in the Brain

Ketone bodies, known for their role in energy metabolism during fasting, have been shown to directly interact with damaged proteins in the brain, aiding their clearance through autophagy. Researchers discovered that the ketone body β-hydroxybutyrate alters the solubility of misfolded proteins, facilitating their removal and reducing pathological aggregation.

Featured Neurology Neuroscience

·October 28, 2022·6 min read

Cellular Housekeeping Process Implicated in Huntington’s Disease

Study reveals how aging impairs autophagy and how enhancing autophagy can prevent cells from dying in Huntington's disease.

Featured Genetics Neuroscience Open Neuroscience Articles

·June 5, 2022·3 min read

Studying Autophagy to Help Us Understand the Mechanisms of Aging-Related Diseases

Researchers have identified the cellular and molecular mechanisms that regulate selective autophagy.

Featured Neurology Neuroscience

·June 2, 2022·5 min read

Evidence Mounts for Alternate Origins of Alzheimer’s Disease Plaques

A new mouse study reveals a breakdown in the process that clears brain cells of waste products precedes the buildup of amyloid plaques associated with Alzheimer's disease.

This shows the outline of a woman and a brain

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·March 11, 2022·2 min read

Brain Stress Factor Regulates Obesity

FKBP51, a protein linked to depression and anxiety disorders, also acts as a link between the stress response system and metabolic processes.

Featured Neurology Neuroscience

·July 15, 2021·4 min read

Autophagy May Be the Key to Finding Treatments for Early Huntington’s Disease

Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.

Brain Cancer Featured Neurology Neuroscience

·December 23, 2020·4 min read

Anti-Diarrhea Drug Drives Cancer Cells to Cell Death

Loperamide, an anti-diarrhea medication, induces autophagy in glioblastoma brain cancer cells.

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·August 9, 2019·3 min read

How chronic stress causes brain damage

Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.

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·July 19, 2019·3 min read

Taking out the Protein Garbage Becomes More Difficult as Neurons Age

In aging mice, the number of autophagosomes is significantly decreased, and pronounced defects in the structure of autophagosomes increased. Turning on the WIPI2B protein restores autophagosome formation in aged neurons.

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·April 18, 2019·4 min read

Blood pressure drug shows promise for treating Parkinson’s and dementia in animal study

Felodipine, a common hypertension medication, induces autophagy and clears aggregate-prone proteins associated with neurodegenerative diseases. The study reveals the drug clears mutant alpha-synuclein in the brains of mice at plasma concentrations to those seen in humans taking the medication. Felodipine appears to have some neuroprotective properties in mouse models of neurodegenerative diseases.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·April 10, 2019·4 min read

Protein pileup affects social behaviors through altered brain signaling

Study implicates disrupted autophagy and protein aggregation in the pathogenesis of autism schizophrenia and social behavior deficits in other disorders.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 2, 2019·2 min read

Hyperactive Immune System Implicated in Aging Brain Disorders

According to a new study, the immune system may play a critical role in damage associated with neurodegenerative disorders such as Alzheimer's disease and ALS. The study reports altering Cdk5 results in the death of dopamine neurons and slowed autophagy.