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autophagy

Featured Genetics Neuroscience Open Neuroscience Articles

·February 2, 2016·3 min read

A Closer Look at Autophagy

A new closer look at the complexity of autophagy.

The image shows a single striatal neuron (yellow) transfected with nuclear inclusion (orange) mHtt, other neurons in background (blue).

Featured Genetics Neurology

·January 5, 2015·4 min read

Animal Study Points to a Treatment for Huntington’s Disease

Researchers improve motor function and reduce brain shrinkage in animal models of HD by adjusting the levels of a signaling protein.

Brain Cancer Featured Neurology Neuroscience

·December 23, 2020·4 min read

Anti-Diarrhea Drug Drives Cancer Cells to Cell Death

Loperamide, an anti-diarrhea medication, induces autophagy in glioblastoma brain cancer cells.

Featured Neurology Neuroscience

·July 15, 2021·4 min read

Autophagy May Be the Key to Finding Treatments for Early Huntington’s Disease

Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 18, 2019·4 min read

Blood pressure drug shows promise for treating Parkinson’s and dementia in animal study

Felodipine, a common hypertension medication, induces autophagy and clears aggregate-prone proteins associated with neurodegenerative diseases. The study reveals the drug clears mutant alpha-synuclein in the brains of mice at plasma concentrations to those seen in humans taking the medication. Felodipine appears to have some neuroprotective properties in mouse models of neurodegenerative diseases.

Nine petri dishes with crystal violet staining for live cells.

Brain Cancer Featured

·September 24, 2015·3 min read

Blood Thinners and Antidepressants Cause Autophagy in Mouse Models of Brain Cancer

According to researchers, combining tricyclic antidepressants with blood thinners increased tumor autophagy in mouse models of glioblastoma brain cancer.

Featured Neurology

·September 11, 2017·4 min read

Body’s Own Defense Against ALS Actually Drives Disease Progression at Later Stages

In early stages of ALS, autophagy helps to suppress disease progression, but accelerates the spread as the disease enters into later stages, researchers report.

This shows the outline of a woman and a brain

Featured Neuroscience Open Neuroscience Articles

·March 11, 2022·2 min read

Brain Stress Factor Regulates Obesity

FKBP51, a protein linked to depression and anxiety disorders, also acts as a link between the stress response system and metabolic processes.

Featured Genetics Neurology

·August 21, 2015·5 min read

Break in Working Relationship Between Two Trash Clearing Proteins May Result in Parkinson’s Disease

According to a new study, when two debris clearing proteins don't work together as they should, Parkinson's disease can occur.

The image shows role of autophagy in Aβ secretion from neurons.

Featured Neurology Open Neuroscience Articles

·October 3, 2013·2 min read

Cell Auto Cleaning Mechanism Mediates the Formation of Plaques in Alzheimer’s

Using transgenic mice, researchers find a lack of autophagy in neurons prevents the secretion of amyloid beta and the formation of β-amyloid plaques in the brain.

Featured Neurology Neuroscience

·October 28, 2022·6 min read

Cellular Housekeeping Process Implicated in Huntington’s Disease

Study reveals how aging impairs autophagy and how enhancing autophagy can prevent cells from dying in Huntington's disease.

Featured Neurology

·December 13, 2017·3 min read

Cellular Self Digestion Process Triggers Autoimmune Disease

A new study reveals how autophagy in certain immune cells can lead to the immune system attacking the central nervous system. The findings have implications for the treatment of autoimmune diseases, like multiple sclerosis.

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