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autophagy

·August 12, 2015·4 min read

Genetic Mutation Leads Transport Defect in ALS

Researchers have identified a transport defect in models of familial ALS which leads to the accumulation of damaged components.

This image shows the proposed role of myelinophagy in a Schwann cell after nerve injury and axon degeneration.

Featured Neuroscience

·July 6, 2015·4 min read

Schwann Cells Clear Damaged Myelin and Guide Regeneration Following Nerve Damage

A new study reveals how Schwann cells in the PNS degrade myelin following nerve injury.

This image shows the stem cell derived motor neurons from an ALS patient.

Featured Genetics Neurology

·February 19, 2015·6 min read

New ALS Gene and Signaling Pathways Identified

Researchers have identified a new gene associated with ALS.

The image shows a single striatal neuron (yellow) transfected with nuclear inclusion (orange) mHtt, other neurons in background (blue).

Featured Genetics Neurology

·January 5, 2015·4 min read

Animal Study Points to a Treatment for Huntington’s Disease

Researchers improve motor function and reduce brain shrinkage in animal models of HD by adjusting the levels of a signaling protein.

This image is a neuron from the brain of a young person with autism.

Autism Electrophysiology Featured

·August 21, 2014·5 min read

Children with Autism Have Extra Synapses in Brain

According to a new study, children with autism have an excess of synapses in the brain, due to a slowdown of the normal pruning process during development.

This image is a brain slice showing glycogen accumulation in the brain.

Featured Neuroscience

·February 28, 2014·4 min read

Researchers Reveal the Dual Role of Brain Glycogen

Researchers report an accumulation of glycogen in Lafora disease directly causes apoptosis, triggers autophagy and synaptic failure.

The image shows role of autophagy in Aβ secretion from neurons.

Featured Neurology Open Neuroscience Articles

·October 3, 2013·2 min read

Cell Auto Cleaning Mechanism Mediates the Formation of Plaques in Alzheimer’s

Using transgenic mice, researchers find a lack of autophagy in neurons prevents the secretion of amyloid beta and the formation of β-amyloid plaques in the brain.