Summary: A new study reveals antibiotics given to pregnant women with Group B Streprococcus during labor can affect a baby’s development of gut bacteria.Source: McMaster University.Antibiotics administered during labour for Group B Streptococcus (GBS) affect the development of gut bacteria in babies, according to a study from McMaster University.The research showed that babies exposed to the antibiotics for GBS during labour had a delay in the maturation of their gut bacteria, known as microbiota. The data also showed that this delay increased with longer durations of exposure to the antibiotics.While the effects of antibiotics for GBS on the gut bacteria in babies was dramatic at early time points, they largely disappeared by 12 weeks of age.The results were published today in the journal Scientific Reports.“Early life microbial colonization and succession is critically important to healthy development, with impacts on metabolic and immunologic processes throughout life,” said Jennifer Stearns, the study’s first author, an assistant professor of medicine at McMaster University’s Michael G. DeGroote School of Medicine and a scientist of the University’s Farncombe Family Digestive Health Research Institute.One out of every three or four pregnant women test positive for Group B Streptococcus during routine screening and the majority choose to receive antibiotic prophylaxis during labour to prevent GBS transmission to their infant at birth. Infant infections can lead to serious illness including meningitis and death in a very small number of infants, and antibiotic treatment is an important prevention strategy.“Our research indicates there is a delay in the expansion of the dominant infant gut colonizer, called Bifidobacterium, when infants are exposed to antibiotics for GBS prevention during vaginal labour,” said Stearns.“It’s a good sign that bacterial groups recover by 12 weeks but it’s still unclear what these findings mean for infant health, especially since early infancy is such an important developmental time.”The gut bacteria development of the infants was tested at four points over the first 12 weeks of life, including at three days, 10 days, six weeks and 12 weeks. NeuroscienceNews.com image is credited to McMaster University.The study utilized data from 74 mother-infant pairs in the McMaster pilot cohort called Baby & Mi. Participants came from low-risk populations in Hamilton and Burlington, Ontario.The gut bacteria development of the infants was tested at four points over the first 12 weeks of life, including at three days, 10 days, six weeks and 12 weeks.The babies were healthy, full-term, breast-fed babies predominantly born vaginally, with a small percentage born by C-section that were also exposed to antibiotics to prevent surgical infection. As in previous studies, babies born by C-section had delayed expansion of the key gut colonizer compared to babies born vaginally without exposure.Researchers at McMaster are using this study as a launching point for further research using the Baby & Mi cohort.“A larger study is underway that will determine the long-term consequences of antibiotics administered during labour for GBS on both microbial succession and on health and disease risk,” said Stearns. “This will help us explore in greater depth the influence of maternal and infant variables on the infant gut microbiome.”[divider]About this neuroscience research article[/divider]Funding: The study was funded by the Hamilton Academic Health Sciences Organization.Principal investigators on the study included Eileen Hutton, assistant dean of midwifery, and professor of obstetrics and gynecology at McMaster and Katherine Morrison, associate professor of pediatrics, and co-director of MAC-Obesity (Metabolism and Childhood Obesity Research Program) at McMaster.See alsoFeaturedNeuroscienceNeuroscience Videos·May 12, 2020Researchers find the ‘brain’s steering wheel’ in the brainstem of miceAdditional researchers came from McMaster’s departments of medicine, pediatrics, obstetrics and gynecology, biochemistry and biomedical sciences, and health research methods, evidence, and impact, as well as the Midwifery Education Program and the Farncombe Family Digestive Health Research Institute.Source: Veronica McGuire – McMaster University Publisher: Organized by NeuroscienceNews.com. Image Source: NeuroscienceNews.com image is in the public domain. Original Research: Full open access research for “Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants” by Jennifer C. Stearns, Julia Simioni, Elizabeth Gunn, Helen McDonald, Alison C. Holloway, Lehana Thabane, Andrea Mousseau, Jonathan D. Schertzer, Elyanne M. Ratcliffe, Laura Rossi, Michael G. Surette, Katherine M. Morrison & Eileen K. Hutton in Scientific Reports. Published online November 28 2017 doi:10.1038/s41598-017-16606-9[divider]Cite This NeuroscienceNews.com Article[/divider][cbtabs][cbtab title=”MLA”]McMaster University “Antibiotics Administered During Labor Delay Healthy Gut Bacteria in Babies.” NeuroscienceNews. NeuroscienceNews, 28 November 2017. <https://neurosciencenews.com/babies-antibiotics-microbiome-8047/>.[/cbtab][cbtab title=”APA”]McMaster University (2017, November 28). Antibiotics Administered During Labor Delay Healthy Gut Bacteria in Babies. NeuroscienceNews. Retrieved November 28, 2017 from https://neurosciencenews.com/babies-antibiotics-microbiome-8047/[/cbtab][cbtab title=”Chicago”]McMaster University “Antibiotics Administered During Labor Delay Healthy Gut Bacteria in Babies.” https://neurosciencenews.com/babies-antibiotics-microbiome-8047/ (accessed November 28, 2017).[/cbtab][/cbtabs]AbstractIntrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infantsEarly life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with uncomplicated pregnancies. Here we compare bacterial community succession in infants born vaginally, with no exposure to antibiotics (n = 53), with infants who were exposed to intrapartum antibiotic prophylaxis (IAP) for Group B Streptococcus (GBS; n = 14), and infants born by C-section (n = 7). Molecular profiles of the 16 S rRNA genes indicate that there is a delay in the expansion of Bifidobacterium, which was the dominate infant gut colonizer, over the first 12 weeks and a persistence of Escherichia when IAP for GBS exposure is present during vaginal labour. Longer duration of IAP exposure increased the magnitude of the effect on Bifidobacterium populations, suggesting a longer delay in microbial community maturation. As with prior studies, we found altered gut colonisation following C-section that included a notable lack of Bacteroidetes. This study found that exposure of infants to IAP for GBS during vaginal birth affected aspects of gut microbial ecology that, although dramatic at early time points, disappeared by 12 weeks of age in most infants.“Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants” by Jennifer C. Stearns, Julia Simioni, Elizabeth Gunn, Helen McDonald, Alison C. Holloway, Lehana Thabane, Andrea Mousseau, Jonathan D. Schertzer, Elyanne M. Ratcliffe, Laura Rossi, Michael G. Surette, Katherine M. Morrison & Eileen K. Hutton in Scientific Reports. Published online November 28 2017 doi:10.1038/s41598-017-16606-9[divider]Feel free to share this Neuroscience News.[/divider]Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. You can cancel your subscription any time.