Obese mice treated with the TSLP cytokine showed a significant loss in abdominal fat and weight. The fat loss was not associated with reduced food intake or faster metabolism, instead the cytokine stimulated the immune system to release lipids via the skin's oil-producing sebaceous glands.
Piezo1 limits the potential of regulatory T cells (Treg) to mitigate autoimmune neuroinflammation. Inhibiting Piezo1 could lead to new treatments for autoimmune disorders like multiple sclerosis.
Scars and lesions on the brain and spinal cord offer clues as to why progressive disability occurs in patients with multiple sclerosis.
A new theory proposes an imbalance of blood proteins involved in the immune system and in blood clotting networks leads to inflammation that contributes to the development of psychosis.
A diet rich in foods containing isoflavone, a plant-based compound found in legumes, chickpeas, and peanuts, that resembles estrogen, protects against multiple sclerosis symptoms in mouse models.
Researchers found lymph-node-like structures close to glioma brain tumors in cancer patients. The study reveals immune cells within these structures can be activated to attack the brain tumor.
Researchers report a cleaner living environment may not detrimentally impact a child's developing immune system, as current theories suggest.
More frequent hospital and doctor's office visits in the years leading up to multiple sclerosis diagnosis with early MS type symptoms are usually associated with a prodromal phase of the disease, when they should be regarded as an ongoing progression of the autoimmune disorder.
Sustained microglia activation leads to the cells becoming senescent. This leads to an accelerated accumulation of amyloid in the brain, influencing the early stages of Alzheimer's development.
Secondary infections and novel inflammatory events, even ones that occur external to the brain, amplify the brain's immune response and detrimentally impact cognition in mouse models of Alzheimer's disease.