Zebrafish study finds antibiotics can have detrimental effects on the descendants of those exposed to them, including weaker immune systems.
Study reveals a causal mechanism for pain reduction may be due to an antibiotic-induced shift in the gut's amino acid concentrations.
Early-life exposure to antibiotics could impact brain development in areas associated with emotional and cognitive function, a new study reports. Researchers found penicillin exposure in infant mice altered the microbiome and gene expression in key areas of the developing brain.
Researchers have identified an association between antibiotics administered to children aged two and under, and an increased risk of ongoing conditions ranging from ADHD to obesity. Children exposed to numerous courses of antibiotics as toddlers were more likely to be diagnosed with continuous conditions later in childhood. The study speculates that while antibiotics may only have a transient effect on the developing microbiome, this may have an impact on long-term illness.
Early-life exposure to antibiotics may impact brain signaling pathways associated with social behavior and pain regulation. Young mice treated with antibiotics had reduced expression of receptors that mediate endorphin, oxytocin, and vasopressin signaling in the frontal cortex.
Immunization with the vaccines for pneumococcal conjugate and rotavirus reduces the rates of acute respiratory infections and gastrointestinal infections in small children, thus reducing the need for antibiotic medications. Researchers say if universal childhood vaccination is achieved, an additional 40 million cases of antibiotic-treated illnesses could be prevented each year.
Mouse study reveals the antibiotic azlocillin completely kills off the Borrelia burgdorferi bacteria at the onset of Lyme disease. Findings also suggest the drug could be effective for treating patients infected with drug-tolerant bacteria that may cause lingering symptoms.
Ethnobotanical plant extracts, including Ghanaian quinine and Japanese knotweed, show strong activity against B.burgdorferi, outperforming current antibiotics for the treatment of Lyme disease.
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A new deep learning algorithm helped researchers identify a powerful new antibiotic compound that kills many of the world's most problematic, disease-causing bacterias, including those which have so far been resistant to common antibiotics.
Mothers who were prescribed macrolide antibiotics, including erythromycin and azithromycin, early in pregnancy had an increased risk of their child being born with malformations, specifically cardiovascular malformations. However, researchers found no link between exposure to these antibiotics and an increased risk of neurodevelopmental disorders.
Gentamicin and G418, two aminoglycoside antibiotics, were effective at correcting genetic mutations associated with a specific form of frontotemporal dementia. The findings are promising for the treatment of frontotemporal dementia.