Three Types of Depression Identified

Summary: Using neuroimaging technology, researchers have identified three different subtypes of depressive disorder, including one that seems to be untreatable by common SSRI antidepressants.

Source: OIST.

According to the World Health Organization, nearly 300 million people worldwide suffer from depression and these rates are on the rise. Yet, doctors and scientists have a poor understanding of what causes this debilitating condition and for some who experience it, medicines don’t help.

Scientists from the Neural Computational Unit at the Okinawa Institute of Science and Technology Graduate University (OIST), in collaboration with their colleagues at Nara Institute of Science and Technology and clinicians at Hiroshima University, have for the first time identified three sub-types of depression. They found that one out of these sub-types seems to be untreatable by Selective Serotonin Reuptake Inhibitors (SSRIs), the most commonly prescribed medicines for the condition. The study was published in the journal Scientific Reports.

Serotonin is a neurotransmitter that influences our moods, interactions with other people, sleep patterns and memory. SSRIs are thought to take effect by boosting the levels of serotonin in the brain. However, these drugs do not have the same effect on everyone, and in some people, depression does not improve even after taking them. “It has always been speculated that different types of depression exist, and they influence the effectiveness of the drug. But there has been no consensus,” says Prof. Kenji Doya.

For the study, the scientists collected clinical, biological, and life history data from 134 individuals — half of whom were newly diagnosed with depression and the other half who had no depression diagnosis- using questionnaires and blood tests. Participants were asked about their sleep patterns, whether or not they had stressful issues, or other mental health conditions.

Researchers also scanned participants’ brains using magnetic resonance imaging (MRI) to map brain activity patterns in different regions. The technique they used allowed them to examine 78 regions covering the entire brain, to identify how its activities in different regions are correlated. “This is the first study to identify depression sub-types from life history and MRI data,” says Prof. Doya.

With over 3000 measurable features, including whether or not participants had experienced trauma, the scientists were faced with the dilemma of finding a way to analyze such a large data set accurately. “The major challenge in this study was to develop a statistical tool that could extract relevant information for clustering similar subjects together,” says Dr. Tomoki Tokuda, a statistician and the lead author of the study. He therefore designed a novel statistical method that would help detect multiple ways of data clustering and the features responsible for it. Using this method, the researchers identified a group of closely-placed data clusters, which consisted of measurable features essential for accessing mental health of an individual. Three out of the five data clusters were found to represent different sub-types of depression.

a woman crying
The three distinct sub-types of depression were characterized by two main factors: functional connectivity patterns synchronized between different regions of the brain and childhood trauma experience. NeuroscienceNews.com image is in the public domain.

The three distinct sub-types of depression were characterized by two main factors: functional connectivity patterns synchronized between different regions of the brain and childhood trauma experience. They found that the brain’s functional connectivity in regions that involved the angular gyrus — a brain region associated with processing language and numbers, spatial cognition, attention, and other aspects of cognition — played a large role in determining whether SSRIs were effective in treating depression.

Patients with increased functional connectivity between the brain’s different regions who had also experienced childhood trauma had a sub-type of depression that is unresponsive to treatment by SSRIs drugs, the researchers found. On the other hand, the other two subtypes — where the participants’ brains did not show increased connectivity among its different regions or where participants had not experienced childhood trauma — tended to respond positively to treatments using SSRIs drugs.

This study not only identifies sub-types of depression for the first time, but also identifies some underlying factors and points to the need to explore new treatment techniques. “It provides scientists studying neurobiological aspects of depression a promising direction in which to pursue their research,” says Prof. Doya. In time, he and his research team hope that these results will help psychiatrists and therapists improve diagnoses and treat their patients more effectively.

About this neuroscience research article

Source: OIST
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Open access research for “Identification of depression subtypes and relevant brain regions using a data-driven approach” by Tomoki Tokuda, Junichiro Yoshimoto, Yu Shimizu, Go Okada, Masahiro Takamura, Yasumasa Okamoto, Shigeto Yamawaki & Kenji Doya in Scientific Reports. Published September 20 2018.
doi:10.1038/s41598-018-32521-z

Cite This NeuroscienceNews.com Article

[cbtabs][cbtab title=”MLA”]OIST”Three Types of Depression Identified.” NeuroscienceNews. NeuroscienceNews, 31 October 2018.
<https://neurosciencenews.com/three-depression-types-10126/>.[/cbtab][cbtab title=”APA”]OIST(2018, October 31). Three Types of Depression Identified. NeuroscienceNews. Retrieved October 31, 2018 from https://neurosciencenews.com/three-depression-types-10126/[/cbtab][cbtab title=”Chicago”]OIST”Three Types of Depression Identified.” https://neurosciencenews.com/three-depression-types-10126/ (accessed October 31, 2018).[/cbtab][/cbtabs]


Abstract

Identification of depression subtypes and relevant brain regions using a data-driven approach

It is well known that depressive disorder is heterogeneous, yet little is known about its neurophysiological subtypes. In the present study, we identified neurophysiological subtypes of depression related to specific neural substrates. We performed cluster analysis for 134 subjects (67 depressive subjects and 67 controls) using a high-dimensional dataset consisting of resting state functional connectivity measured by functional MRI, clinical questionnaire scores, and various biomarkers. Applying a newly developed, multiple co-clustering method to this dataset, we identified three subtypes of depression that are characterized by functional connectivity between the right Angular Gyrus (AG) and other brain areas in default mode networks, and Child Abuse Trauma Scale (CATS) scores. These subtypes are also related to Selective Serotonin-Reuptake Inhibitor (SSRI) treatment outcomes, which implies that we may be able to predict effectiveness of treatment based on AG-related functional connectivity and CATS.

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  1. Hola. Padezco depresión desde hace 27 años, pero no tome antidepresivos de manera regular, solo lo hacia de manera muy esporádica, en una ocasión me recetaron unas drogas de diseño enmascaradas como medicamento y en esa ocasión tuve una mejoría notable pero con marcados síntomas psicóticos, ya que tenía mucha energía y ocurrió un incidente de agresividad y me encerraron por varios meses en un psiquiátrico y salí muy deprimido de ahí, luego me recetaron por varios años de antidepresivos y antipsicóticos y no mejoró mi depresión, sino que seguí mal, sólo mejoré un poco con el ejercicio pero no logre curarme definitivamente y no consigo funcionar en el trabajo o el estudio. ¿Habrá alguna opción para las personas que no respondemos a los medicamentos ni al ejercicio?

  2. My son is suffering from PSSD post SSRI sexual dysfunction- it is accompanied by complete lack of libido anhedonia (no emotions) loss of taste, chronic insomnia, cognitive changes, genital anesthesia, akathisia- please please do research on this there are thousands who suffer from this and no one is mentioning it on the research forums. It is a desperate situation and many are choosing suicide rather than live like a zombie. Please help.

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