Differences in the expression of gene transcripts shed light on how mental health disorders with shared genetic risk factors differ in onset, symptoms, course of progression, and treatment responses. Read More
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Using data from neuroimaging, a machine learning algorithm has identified key functional neural connections that could serve as a biomarker in the diagnosis of major depressive disorder. Read More
Two doses of psilocybin in combination with therapy rapidly and significantly reduces symptoms in those with major depressive disorder. The effects appear to last for up to four weeks. Read More
Sleep disturbances may be an outcome of Alzheimer's in those with a genetic predisposition, but not a cause of dementia. Those with genetic risk factors for Alzheimer's tend to have shorter sleep durations and are more likely to be early risers but are less likely to suffer from insomnia. Read More
Study reports that almost 30% of women and 17% of men experience major depressive disorder episodes over the course of their lives. Read More
Examining the impact of eight types of early life stress on the onset of youth-onset depression, researchers found some had little impact on the development of the psychological disorder. Emotional abuse was more strongly associated with the development of major depressive disorder than other early stressors, such as poverty. Read More
Comparing data from multiple neuroimaging studies, researchers found shared brain structural abnormalities between four psychiatric disorders, including schizophrenia and bipolar disorder. They also identified brain signatures unique to each condition. Read More
Study reveals how the brain's opioid system is linked to mood changes associated with depression and anxiety. Neuroimaging revealed, in those with depression, there is a decreased number of opioid receptors in specific areas of the brain. Read More
Using patient-derived adult stem cells, researchers found fish oil created an antidepressant response. Read More
During periods where personal choices of activities are constrained, natural mood regulation becomes impaired, resulting in an increased risk of depression. Read More
A new substance named Lu AF60097 may help reduce side effects from tricyclic antidepressants in those with severe depression. Read More
The largest genetic map of mental health disorders to date reveals there are three groups of highly genetically related disorders among eight psychiatric disorders. A gene related to nervous system development is a risk factor for all eight disorders studied. The RBFOX1 gene is implicated in seven of the eight disorders. ADHD and depression share 44% of genetic risk factors common in the general population. 109 pleiotropic loci affect more than one disorder. These pleiotropic loci are within genes that show heightened expression in the brain through the lifespan, beginning during the second trimester of pregnancy. Read More
