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MDD

·January 28, 2022·4 min read

Patients With Schizophrenia, Major Depression and Bipolar Disorder Have Distinct Reward Neural Mechanisms

While patients with schizophrenia, major depressive disorder, and bipolar disorder experience a lack of motivation and anhedonia, the neural patterns of emotion-behavior dissociation differ between the disorders.

Featured Neuroscience Open Neuroscience Articles Psychology

·January 11, 2022·3 min read

Why Severe Depression Affects Women and Men Differently

Researchers found alterations in different parts of the brain in males and females with severe depression. The findings also reveal a specific biomarker for depression in blood samples of women.

This is a cartoon of a head and a man standing behind, pulling out string from the brain

Featured Neuroscience Open Neuroscience Articles Psychology

·December 5, 2021·4 min read

New Insight Into How Antidepressant Drugs Work

Hippocampal HCN channels are more highly expressed in people with major depressive disorder. Antidepressants that increase cAMP signaling interfere with TRIP8b's ability to bind to HCN channels, helping to restore cognitive ability in those with MDD.

Featured Neuroscience Psychology

·July 28, 2021·6 min read

Improved Learning Processes Tied to Reduced Symptoms of Depression

Specific neural learning processes are linked to symptoms of depression. Improvements in the learning processes were associated with overall improvements in depression symptoms.

Featured Psychology

·June 9, 2021·4 min read

Low Doses of “Laughing Gas” Could Be Fast, Effective Treatment for Severe Depression

Nitrous oxide, a common anesthesia most often associated with dental procedures, may have a new purpose. Researchers found a single inhalation of 25% nitrous oxide gas was effective at alleviating symptoms of depression in those with a treatment-resistant form of the mental health disorder.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·April 6, 2021·6 min read

Accelerated Cellular Aging Associated With Mortality Seen in Depressed Individuals

DNA markers in cells of patients with major depressive disorder appear to be two years older than markers in cells of people without the mental health disorder.

Featured Genetics Neuroscience Psychology

·March 23, 2021·5 min read

Large-Scale Genome Analysis Identifies Differences by Sex in Major Psychiatric Disorders

Researchers found that while there are genetic overlaps between the sexes in relation to mental health disorders, there are also sex-specific differences in how genes related to the immune system, central nervous system, and blood vessels affect people with mental health problems.

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Featured Genetics Neuroscience Psychology

·February 8, 2021·5 min read

Distinctness of Mental Disorders Traced to Differences in Gene Readouts

Differences in the expression of gene transcripts shed light on how mental health disorders with shared genetic risk factors differ in onset, symptoms, course of progression, and treatment responses.

Featured Open Neuroscience Articles Psychology

·December 7, 2020·3 min read

Machine Learning Identifies New Brain Network Signature of Major Depression

Using data from neuroimaging, a machine learning algorithm has identified key functional neural connections that could serve as a biomarker in the diagnosis of major depressive disorder.

Featured Psychology

·November 4, 2020·5 min read

Psychedelic Treatment With Psilocybin Relieves Major Depression

Two doses of psilocybin in combination with therapy rapidly and significantly reduces symptoms in those with major depressive disorder. The effects appear to last for up to four weeks.

Featured Neurology

·August 19, 2020·3 min read

Is Risk of Alzheimer’s Linked to Specific Sleep Patterns?

Sleep disturbances may be an outcome of Alzheimer's in those with a genetic predisposition, but not a cause of dementia. Those with genetic risk factors for Alzheimer's tend to have shorter sleep durations and are more likely to be early risers but are less likely to suffer from insomnia.