Glycine, a common amino acid, appears to play a role in the development of major depression, anxiety, and other mood-related disorders.
Men are more likely to have a dysregulated HPA axis that is associated with depressive symptoms, while women have higher levels of binding proteins for stress hormones that may prevent dysregulation of the HPA axis. The findings shed new light on how stress hormones impact dopamine transmission and how this impacts depression on a sex-specific basis.
Treatments for depression including ECT and antidepressants increase brain connectivity in those with clinical depression.
D-Cycloserine, an antibiotic used for the treatment of tuberculosis, increases the effectiveness of transcranial magnetic stimulation for those with major depressive disorder.
Neuroimaging study reveals subtle size differences in the prefrontal region of the brain in young people with major depressive disorders and suicidal behaviors.
The direction of appetite change associated with depression was linked to specific changes in the brain's reward system.
The amygdala-pons connectivity in the pons-corticolimbic network is significantly stronger in patients with major depressive disorder.
Using psychiatric medications to treat mental health disorders in children and adolescents does not increase the risk of developing substance use disorders later in life. In fact, pharmacological interventions reduce the risk of developing SUD for those with MDD, ADHD, and psychotic disorders.
Researchers have identified a blood biomarker that predicts the risk of suicide in patients with major depressive disorder. The biomarker also can help researchers understand the molecular changes in suicide victims.
Study reports a significant decline in smoking for those with major depression and substance use disorders, signifying smoking cessation treatments and campaigns are effective in targeting those in groups considered high risk for developing nicotine addiction.
Over 22% of adults who were chronically exposed to parental domestic violence as children developed major depressive disorder later in life. 1 in 6 adults who witnessed PDV developed anxiety disorders, and over 25% later developed substance use disorders.
Researchers identified a link between major depressive disorder and mechanical alterations in blood cells.
