The largest genetic map of mental health disorders to date reveals there are three groups of highly genetically related disorders among eight psychiatric disorders. A gene related to nervous system development is a risk factor for all eight disorders studied. The RBFOX1 gene is implicated in seven of the eight disorders. ADHD and depression share 44% of genetic risk factors common in the general population. 109 pleiotropic loci affect more than one disorder. These pleiotropic loci are within genes that show heightened expression in the brain through the lifespan, beginning during the second trimester of pregnancy.
Findings reveal it is possible to predict the risk of a person with MDD lapsing back into depression after stopping antidepressants. Those who relapse take longer to decide how much effort to invest for a reward.
Those with 22q11.2 deletion syndrome had significantly lower brain volume, as well as lower volumes in specific structures, including the thalamus, hippocampus, and amygdala.
Exposure to household pet dogs in the early years of life was associated with a significantly decreased risk of being diagnosed with schizophrenia later in life.
The side effects of administering ketamine to treat major depressive disorder are mild and persist for no longer than four hours, researchers report. Most of the side effects peaked within an hour of treatment, and many patients reported the effects as being significantly reduced two hours post ketamine administration.
Long term outcome data of patients with treatment-resistant depression found subcallosal cingulate deep brain stimulation (SCC DBS) was both effective at relieving symptoms and safe.