Poor Sleep Quality in Middle Age Linked to Future Cognitive Decline

Summary: New research suggests that disrupted sleep in one’s 30s and 40s may lead to memory and cognitive problems a decade later. While the study doesn’t establish a causal relationship, it highlights an association between sleep quality and cognitive health.

Researchers followed 526 participants for 11 years and found that those with the most disrupted sleep had over twice the odds of experiencing poor cognitive performance later in life. This emphasizes the importance of addressing sleep quality for long-term cognitive health.

Key Facts:

  1. Disrupted sleep in middle age can increase the risk of cognitive decline later in life.
  2. Sleep quality, rather than quantity, plays a significant role in cognitive health.
  3. The study highlights the need for further research to understand the connection between sleep and cognition at different life stages.

Source: AAN

People who have more disrupted sleep in their 30s and 40s may be more likely to have memory and thinking problems a decade later, according to new research published in the January 3, 2024, online issue of Neurology.

The study does not prove that sleep quality causes cognitive decline. It only shows an association.

This shows a man sleeping.
Of the 175 people with the most disrupted sleep, 44 had poor cognitive performance 10 years later, compared to 10 of the 176 people with the least disrupted sleep. Credit: Neuroscience News

“Given that signs of Alzheimer’s disease start to accumulate in the brain several decades before symptoms begin, understanding the connection between sleep and cognition earlier in life is critical for understanding the role of sleep problems as a risk factor for the disease,” said study author Yue Leng, PhD, of the University of California, San Francisco.

“Our findings indicate that the quality rather than the quantity of sleep matters most for cognitive health in middle age.”

The study involved 526 people with an average age of 40. They were followed for 11 years.

Researchers looked at participants’ sleep duration and quality. Participants wore a wrist activity monitor for three consecutive days on two occasions approximately one year apart to calculate their averages. Participants slept for an average of six hours.

Participants also reported bedtimes and wake times in a sleep diary and completed a sleep quality survey with scores ranging from zero to 21, with higher scores indicating poorer sleep quality. A total of 239 people, or 46%, reported poor sleep with a score greater than five.

Participants also completed a series of memory and thinking tests.

Researchers also looked at sleep fragmentation, which measures repetitive short interruptions of sleep. They looked at both the percentage of time spent moving and the percentage of time spent not moving for one minute or less during sleep. After adding these two percentages together, researchers found that participants had an average sleep fragmentation of 19%.

Researchers then divided participants into three groups based on their sleep fragmentation score.

Of the 175 people with the most disrupted sleep, 44 had poor cognitive performance 10 years later, compared to 10 of the 176 people with the least disrupted sleep.

After adjusting for age, gender, race, and education, people who had the most disrupted sleep had more than twice the odds of having poor cognitive performance when compared to those with the least disrupted sleep. There was no difference in cognitive performance at midlife for those in the middle group compared to the group with the least disrupted sleep.

“More research is needed to assess the link between sleep disturbances and cognition at different stages of life and to identify if critical life periods exist when sleep is more strongly associated with cognition,” Leng said. “Future studies could open up new opportunities for the prevention of Alzheimer’s disease later in life.”

The amount of time people slept and their own reports of the quality of their sleep were not associated with cognition in middle age.

A limitation of the study was that due to the small sample size, researchers were unable to fully investigate potential race or gender differences.

Funding: The study was funded by the National Institute on Aging and the National Heart, Lung, and Blood Institute.

About this sleep, aging, and cognition research news

Author: Renee Tessman
Source: AAN
Contact: Renee Tessman – AAN
Image: The image is credited to Neuroscience News

Original Research: The findings will appear in Neurology

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