Blood stem cells use an unexpected method to remove misfolded proteins, and the pathway's activity declines with age. However, boosting the aggrephagy pathway could help prevent age-related diseases.
The ability to dual-task walk and talk begins to decline around the age of 55. This decline is a result of changes to cognition and underlying brain function rather than due to physical changes associated with aging.
Supplementing the amino acid D-serine helped to mitigate some of the age-related changes associated with a decline of the hypothalamic hormone Menin in mouse models.
Aging may hamper the neural processing of emotions conveyed via facial expressions.
People who follow diets rich in leafy greens, olive oil, nuts, and fish, such as the MIND or Mediterranean diet, have fewer amyloid plaques and Tau tangles in their brains than those who follow a more conventional diet.
M1 muscarinic acetylcholine receptor (mAChR) dependent LTP and LTD share a common AMPA trafficking pathway. Either the upregulation of neurotransmitter receptor genes or suppression of the downregulation could improve synaptic dysfunction associated with age-related neurodegeneration. The findings could assist in the creation of new therapies for Alzheimer's disease that target synaptic plasticity.
As the brain ages, microglia adopt dysfunctional states that increase the risk of developing neurodegenerative diseases such as Alzheimer's disease.
As we age, most of us tend to stop paying attention to new music and stick with the songs from our past. Researchers explore why we narrow our horizons for exploring new music as we age and say listening to new tracks can help create new memory bonds and experience new pleasures.
Retired football players who experienced concussions during their careers performed worse on cognitive tests than non-players. The findings add to the growing body of evidence that suggests head injuries experienced by football players accelerate cognitive aging. Researchers say the results underlie the importance of tracking concussion symptoms in football players as opposed to concussion diagnosis.
In adults, levels of GDF11, a gene that is key to the regeneration of murine neural stem cells, are inversely related to depressive episodes. Administering the GDF11 proteins to aging mice reduced depressive states and improved cognition.
Genes linked to inflammation, neurotransmission, and immunity act differently in the brains of those on the autism spectrum compared to neurotypical people. These differences begin during childhood and evolve throughout a person's lifespan.
At any age, regular exercise or physical activity helps to maintain brain function during old age. However, maintaining a frequent workout schedule throughout life was linked to better mental acuity, memory, and cognition later in life.
