Summary: Researchers report the personal odors of healthy animals change when they share an environment with a sick animal. The findings suggest these changes could impact social contact and patterns of disease spread.
Source: Monell Chemical Senses Center.
Odors surround us, providing cues about many aspects of personal identity, including health status. Now, research from the Monell Center extends the scope and significance of personal odors as a source of information about an individual’s health. A new paper in the open-access journal Scientific Reports reveals that the bodily odors of otherwise healthy animals sharing an environment with sick animals become like the odors of the sick animals.
The findings suggest that odor cues associated with sickness can cause biological changes in healthy individuals, potentially impacting social contacts and perhaps even patterns of disease spread.
“Exposure to the odors of sick individuals may trigger protective or preparative responses in their social partners to minimize the risk of impending infection,” said study lead author Stephanie Gervasi, PhD, a Monell chemical ecologist.
Previous Monell work had demonstrated that inflammation leads to bodily odor changes, suggesting that immune-activated odors might signal the presence of disease risk (or possible contagion) to other members of a species.
In the current study, the researchers injected mice with lipopolysaccharide (LPS), a non-infectious bacterial toxin that causes inflammation, activation of the immune system, and other symptoms associated with sickness. The LPS-injected “sick” animals were then housed in the same cages as healthy animals.
Results from bioassays using “sniffer” mice trained to differentiate between urine odors from LPS-injected and healthy animals indicated that healthy partners of sick animals smelled more like sick, as compared to healthy, animals.
A parallel analysis using statistical predictive modeling of urinary odor compounds identified via analytical chemistry confirmed the behavioral bioassay findings: models were more likely to classify odor compounds from healthy mice as sick rather than healthy when the healthy mice were co-housed with sick animals.
Similar results were obtained when the study was repeated with sick and healthy animals that were physically separated by a perforated partition. The partition allowed odors to circulate, strongly suggesting that the changes in the healthy mice were not the result of physical odor transfer.
The combined findings reveal that body odors of healthy animals can change in the presence of odor-based sickness signals.
“This work shows not only that odors signal disease but that they can have strong effects on individuals that detect them,” said Monell behavioral biologist Gary Beauchamp, PhD, one of the paper’s senior authors. “This is a remarkable transfer of information via olfaction that specifically alters physiology and could play a role in disease transfer among individuals in many species.”
Bruce Kimball, PhD, a research chemist from the USDA National Wildlife Research Center Research (NWRC) stationed at Monell and also a senior author, notes that the study’s findings may be particularly relevant to wildlife populations. “This knowledge that healthy animals can emit odors associated with sickness may inform our efforts to use bodily odors to understand how pathogens are transmitted within a population of animals,” he said.
The NWRC has maintained a Field Station at Monell for over 45 years. To date, more than 200 publications on bird and wildlife chemical senses have resulted from the Monell-USDA affiliation, disseminating information on the biology and behavior of many animal and avian species, along with knowledge to aid in effective management of wildlife resources.
Funding: Also contributing to the research were Marianne Opiekun and Talia Martin of Monell. Research reported in the publication was supported by USDA APHIS-WS-NWRC and by grants from the National Institute on Deafness and Other Communication Disorders (DC000014 and DC020296) of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the USDA. Additional support came from private funding by Dr. James Albrecht.
Source: Leslie Stein – Monell Chemical Senses Center
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Zave Smith/Monell Center.
Original Research: Open access research for “Sharing an environment with sick conspecifics alters odors of healthy animals” by Stephanie S. Gervasi, Maryanne Opiekun, Talia Martin, Gary K. Beauchamp & Bruce A. Kimball in Scientific Reports. Published September 24 2018.
doi:10.1038/s41598-018-32619-4
[cbtabs][cbtab title=”MLA”]Monell Chemical Senses Center”Know Someone Sick? Your Own Smell Might Give it Away.” NeuroscienceNews. NeuroscienceNews, 24 September 2018.
<https://neurosciencenews.com/sickness-personal-smell-9903/>.[/cbtab][cbtab title=”APA”]Monell Chemical Senses Center(2018, September 24). Know Someone Sick? Your Own Smell Might Give it Away. NeuroscienceNews. Retrieved September 24, 2018 from https://neurosciencenews.com/sickness-personal-smell-9903/[/cbtab][cbtab title=”Chicago”]Monell Chemical Senses Center”Know Someone Sick? Your Own Smell Might Give it Away.” https://neurosciencenews.com/sickness-personal-smell-9903/ (accessed September 24, 2018).[/cbtab][/cbtabs]
Abstract
Sharing an environment with sick conspecifics alters odors of healthy animals
Body odors change with health status and the odors of sick animals can induce avoidance behaviors in healthy conspecifics. Exposure to sickness odors might also alter the physiology of healthy conspecifics and modify the odors they produce. We hypothesized that exposure to odors of sick (but non-infectious) animals would alter the odors of healthy cagemates. To induce sickness, we injected mice with a bacterial endotoxin, lipopolysaccharide. We used behavioral odor discrimination assays and analytical chemistry techniques followed by predictive classification modeling to ask about differences in volatile odorants produced by two types of healthy mice: those cohoused with healthy conspecifics and those cohoused with sick conspecifics. Mice trained in Y-maze behavioral assays to discriminate between the odors of healthy versus sick mice also discriminated between the odors of healthy mice cohoused with sick conspecifics and odors of healthy mice cohoused with healthy conspecifics. Chemical analyses paired with statistical modeling revealed a parallel phenomenon. Urine volatiles of healthy mice cohoused with sick partners were more likely to be classified as those of sick rather than healthy mice based on discriminant model predictions. Sickness-related odors could have cascading effects on neuroendocrine or immune responses of healthy conspecifics, and could affect individual behaviors, social dynamics, and pathogen spread.
