Insufficient Iron Intake During Pregnancy Has Effect on Infant’s Brain Development

In the first study of its kind, researchers have shown that inadequate maternal iron intake during pregnancy exerts subtle effects on infant brain development. Their findings have been published online by the journal Pediatric Research.

The research–led by principal investigators Bradley S. Peterson, MD, director of the Institute for the Developing Mind at The Saban Research Institute of Children’s Hospital Los Angeles and Catherine Monk, PhD, of Columbia University Medical Center– indicates the potential significance for the child of even modest changes in maternal dietary health.

Dietary iron is required for normal growth and development, and for optimal brain growth in utero. But 35 to 58 percent of healthy women have some degree of iron deficiency, especially in pregnancy. Worldwide, nearly half of pregnant women are anemic, and this severe maternal iron deficiency can have adverse consequences for the developing fetus.

Past animal studies have shown that prenatal brain iron deficiency leads to impaired functioning of the hippocampus, adversely affecting learning and memory, and with delayed maturation of white matter in the brain. Consistent with these findings, it has been shown that newborns with a low iron profile lagged in general motor and neurocognitive development.

In this study, the researchers looked at the organization of newborn brain tissue using Diffusion Tensor Imaging (DTI), a magnetic resonance imaging (MRI) technique. The DTI images – taken at an average of 20 days after birth– were used to associate maternal iron intake during pregnancy to differences in cortical gray matter and, to a lesser extent, in major axonal pathways within the underlying white matter of the brain.

The scientists found that maternal iron intake correlated inversely with fractional anisotropy (FA) – a unit of measurement in DTI that is a useful measurement of tissue organization in the brain–at locations scattered throughout the gray matter of the brain. This suggests that higher dietary iron intake is associated with greater complexity and therefore greater maturity of cortical gray matter and, conversely, that lower dietary iron is associated with lesser complexity and more immaturity of the developing gray matter shortly after birth.

“These findings are consistent with our expectations,” said Peterson, who is also a professor of professor of pediatrics and psychiatry at Keck School of Medicine of the University of Southern California. “Neurons become increasingly more complex in their extensions and connections as the brain matures, and the maturational delays reported previously in animal models and human behavioral studies of iron deficiency would predict that lower iron intake would produce neurons in cortical gray matter that are structurally less complex and more immature. That is what our DTI findings suggest is the case.'”

Brain scans from newborn babies. The caption best describes the image.
Newborn brain images show total maternal prenatal iron intake (purple) correlates with measures of local tissue organization (FA values). Credit: Bradley Peterson, MD, Children’s Hospital Los Angeles.

These correlations were detected in the newborn infants of a sample of 40 healthy adolescent mothers who were adhering to prenatal care and across a range of iron intake. Despite their prenatal care, 14 percent still met clinical criteria for mild anemia, underscoring the health risks in adolescent mothers and their newborn children.

Peterson says that the technical nature of MRI brain assessments limited the number of adolescent women and their infants who could be studied, the findings bear further investigation. “Our imaging findings add brain-based assessments to the growing evidence that common inadequacies in maternal nutrition influence a child’s development, even before birth.”

About this developmental neuroscience research

Additional contributors to the study include Michael K. Georgieff, University of Minnesota Medical School; Dongrong Xu and Xuejun Hao, New York State Psychiatric Institute; Ravi Bansal, Children’s Hospital Los Angeles and the University of Southern California; and Hanna Gustafsson and Julie Spicer, Columbia University Medical Center.

Funding: The research was supported by the National Institute of Mental Health grant # MH093677.

Source: Debra Kain – Children’s Hospital of Los Angeles
Image Credit: The image is credited to Bradley Peterson, MD, Children’s Hospital Los Angeles
Original Research: Abstract for “Maternal Prenatal Iron Status and Tissue Organization in the Neonatal Brain” by Catherine Monk, Michael K. Georgieff, Dongrong Xu, Xuejun Hao, Ravi Bansal, Hanna Gustafsson, Julie Spicer and Bradley S. Peterson in Pediatric Research. Published online November 24 2015 doi:10.1038/pr.2015.248


Maternal Prenatal Iron Status and Tissue Organization in the Neonatal Brain

Children prenatally exposed to inadequate iron have poorer motor and neurocognitive development. No prior study to our knowledge has assessed the influence of maternal prenatal iron intake on newborn brain tissue organization in full term infants

3rd trimester daily iron intake was obtained using the Automated SelfAdministered 24hour Dietary Recall with n=40 healthy pregnant adolescents (14–19 years old). Cord blood ferritin was collected in a subsample (n=16). Newborn (m=39 gestational weeks at birth; range 37–41) Neonatal MRI scans were acquired on a 3.0 Tesla MR Scanner. Diffusion Tensor Imaging (DTI) slices were acquired to measure the directional diffusion of water indexed by fractional anisotropy (FA).

Reported iron intake was inversely associated with newborn FA values (P ≤.0001) predominantly in cortical gray matter. FA findings were similar using cord blood ferritin values.

Higher maternal prenatal iron intake accentuates, and lower intake attenuates, the normal age– related decline in FA values in gray matter, perhaps representing increasing dendritic arborization and synapse formation with higher iron intake. These DTI results suggest that typical variation in maternal iron outside the scope of standard clinical surveillance exerts subtle effects on infant brain development.

“Maternal Prenatal Iron Status and Tissue Organization in the Neonatal Brain” by Catherine Monk, Michael K. Georgieff, Dongrong Xu, Xuejun Hao, Ravi Bansal, Hanna Gustafsson, Julie Spicer and Bradley S. Peterson in Pediatric Research. Published online November 24 2015 doi:10.1038/pr.2015.248

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