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iron

·December 6, 2022·3 min read

How Neurons Respond to Aged-Related Iron Accumulation

Researchers identified two genes that respond to age-related iron accumulation in the substantia nigra. Knockdown of these genes results in severely impairing the cellular tolerance for iron toxicity.

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·August 1, 2022·5 min read

Iron Buildup in Brain Linked to Higher Risk for Movement Disorders

Those with hereditary hemochromatosis who have two copies of the gene mutation that cause the disorder have an increased risk of developing movement disorders including Parkinson's disease.

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·July 10, 2022·4 min read

Stress Affects Fetus’ Ability to Absorb Iron

Chronic stress experienced by a woman in the later stages of pregnancy can affect her fetus' ability to absorb iron by up to 15%. Researchers say the effects of iron deficiency are more noticeable in male fetuses.

This shows hepcidin expression in the brain

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·February 1, 2022·4 min read

Iron Accumulation Linked With Age-Related Cognitive Decline

A breakdown in regulatory mechanisms causes iron to build up in the brain during aging, increasing oxidative stress and increasing the risk of age-related cognitive decline, a new study reports.

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·December 16, 2021·4 min read

Parkinson’s Disease Mutation Misdirects Iron in the Brain

Findings reveal a common Parkinson's disease genetic mutation drives mislocalization of iron in activated microglia.

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·August 20, 2021·3 min read

Physical Exercise Modulates Iron in Alzheimer’s Disease

Regular exercise modulates iron storage and trafficking in the brain and skeletal muscles, and physical activity reduces cortical hepcidin. The findings reveal how exercise can be beneficial for those with Alzheimer's disease.

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·June 9, 2021·1 min read

Elemental Copper and Iron Found Within the Brains of Deceased Alzheimer’s Patients

Researchers found tiny deposits of elemental copper and iron in the brains of Alzheimer's patients. The findings may shed new light on how these elemental metals contribute to Alzheimer's development and progression.

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·September 9, 2020·4 min read

Vitamin B1 Deficiency a Key Factor in the Development of Alcohol-Related Dementia

Researchers hypothesize vitamin B1 (thiamine) deficiency may play a significant role in dementia associated with alcohol use disorder. It is known iron deposits in the brain contribute to neurodegenerative diseases. Those with AUD have elevated levels of both iron in their blood and thiamine deficiency. Thiamine is vital for maintaining the blood-brain barrier. Thiamine deficiency associated with AUD disrupts the integrity of the BBB, allowing for more iron deposits within the brain and leading to oxidative tissue damage.

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·July 3, 2020·5 min read

Brain Iron Accumulation Linked to Cognitive Decline in Alzheimer’s

Iron accumulation in the brain's neocortex has been linked to cognitive decline in people with Alzheimer's disease.

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·February 23, 2020·4 min read

Iron in brain shows cognitive decline in people with Parkinson’s

The measure of iron in the brain may help doctors predict which patients with Parkinson's disease are most likely to develop dementia.

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·January 27, 2020·3 min read

The brain may need iron for healthy cognitive development

Iron levels in the basal ganglia steadily increase throughout development and, in two sub-regions, continue to increase into adulthood. Decreased levels of iron in the putamen was correlated with impaired cognitive performance involving reasoning and spatial processing. Findings suggest the brain requires iron for healthy cognitive development.