Summary: Structural and functional alterations in the cognitive control network contribute to individual variability in memory performance during aging.
Source: Johns Hopkins University
Some older adults without noticeable cognitive problems have a harder time than younger people in separating irrelevant information from what they need to know at a given time, and a new Johns Hopkins University study could explain why.
The findings offer an initial snapshot of what happens in the brain as young and old people try to access long-term memories, and could shed light on why some people’s cognitive abilities decline with age while others remain sharp.
“Your task performance can be impaired not just because you can’t remember, but because you can’t suppress other memories that are irrelevant,” said senior author Susan Courtney, a cognitive neuroscientist at Johns Hopkins. “Some ‘memory problems’ aren’t a matter of memory specifically, but a matter of retrieving the correct information at the right time to solve the problem at hand.”
The findings were just posted in Neurobiology of Aging.
The researchers had 34 young adults (18 to 30) and 34 older adults (65-85) perform a mental arithmetic task while their brain activity was measured through functional magnetic resonance imaging, or fMRI. Other images were also collected to measure the integrity of the connections between brain areas called white matter tracts.
The task compared the participants’ ability to inhibit irrelevant information automatically retrieved from long term memory. They were asked to indicate whether a proposed solution to an addition or multiplication problem was correct or not – for instance 8×4=12 or 8+4=32. These examples would create interference as participants considered the right answer because although they should answer “incorrect,” the proposed solution seems correct at first glance, based on long-term memories of basic math. This interference did not exist when participants were asked to answer clearly false equations like 8×4=22. Making the task even more complicated, the subjects were sometimes asked to switch to multiplication after they saw the addition symbol and vice versa.
Older people were a fraction of a second slower at answering the questions than younger participants, particularly when there was interference, but the more dramatic difference showed up in the brain scans. Older individuals who had more difficulty with interference also had more frontal brain activation than young adults.
The brain imaging demonstrated that in some aging participants, fibers connecting the front and back of the brain appear to have been damaged over the years. However other older individuals had fibers similar to much younger subjects. The greater the integrity of these fibers, the better the participant’s task performance, said lead author Thomas Hinault, a postdoctoral fellow at Johns Hopkins.
“Everyone we studied had good functioning memory, but still we saw differences,” Hinault said. “There are so many disruptions in the world and being able to suppress them is crucial for daily life.”
The researchers were surprised to find that during parts of the task that were the trickiest, where participants had to switch between multiplication and addition and were asked to add after they saw a multiplication command or vice versa, the people with the strongest brain fiber connections counterintuitively performed even better. Something about deliberately exercising the mind in this fashion made the most agile minds even more so.
“If you have good connections between brain networks, that will help,” Courtney said. “If not, you have interference.”
Co-authors included Kevin Larcher of McGill University; Louis Bherer of the Université de Montréal; and Alain Dagher of McGill University.
Source:
Johns Hopkins University
Media Contacts:
Jill Rosen – Johns Hopkins University
Image Source:
The image is in the public domain.
Original Research: Closed access
“Age-related differences in the structural and effective connectivity of cognitive control: a combined fMRI and DTI study of mental arithmetic”. Thomas Hinault, Kevin Larcher, Louis Bherer, Susan M. Courtney, Alain Dagher.
Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2019.06.013
Abstract
Age-related differences in the structural and effective connectivity of cognitive control: a combined fMRI and DTI study of mental arithmetic
Cognitive changes with aging are highly variable across individuals. This study investigated whether cognitive control performance might depend on preservation of structural and effective connectivity in older individuals. Specifically, we tested inhibition following working memory (WM) updating and maintenance. We analyzed diffusion tensor imaging and functional magnetic resonance imaging data in thirty-four young adults and thirty-four older adults, who performed an arithmetic verification task during functional magnetic resonance imaging. Results revealed larger arithmetic interference in older adults relative to young adults after WM updating, whereas both groups showed similar interference after WM maintenance. In both groups, arithmetic interference was associated with larger activations and stronger effective connectivity among bilateral anterior cingulate, bilateral inferior frontal gyrus, and left angular gyrus, with larger activations of frontal regions in older adults than in younger adults. In older adults, preservation of frontoparietal structural microstructure, especially involving the inferior frontaloccipital fasciculus, was associated with reduced interference, and stronger task-related effective connectivity. These results highlight how both structural and functional changes in the cognitive control network contribute to individual variability in performance during aging.
