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TREM2

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·August 11, 2026·3 min read

Study of Brain Immune Cells Reveals New Clues to Alzheimer’s Disease Progression

Researchers have mapped over 830,000 brain immune cells, revealing a protective subtype of microglia that increases with Alzheimer’s progression. This subtype aids in clearing harmful material via the TREM2 pathway. The findings suggest new therapeutic targets focused on bolstering the brain's immune response rather than solely targeting amyloid plaques.

Featured Genetics Neurology Neuroscience

·June 7, 2026·9 min read

Microglial State Transitions Dictate Alzheimer’s

A new study identifies a critical microglial state transition that determines whether pathology progresses toward clinical dementia.

Featured Genetics Neurology Neuroscience

·October 17, 2025·5 min read

New Alzheimer’s Mutation Weakens Brain’s Immune Defense

A new study has identified a mutation in the TREM2 gene that disrupts the brain’s ability to clear toxic amyloid plaques, increasing Alzheimer’s disease risk. The mutation, called T96K, keeps the TREM2 gene in an overactive state that paradoxically weakens microglial “cleanup” activity, especially in females.

Featured Genetics Neurology Neuroscience

·September 30, 2024·5 min read

Genetic Variants Linked to Alzheimer’s Trigger Inflammation in Females

Researchers have discovered that two genetic variants, APOE4 and TREM2 R47H, together cause a harmful inflammatory response in brain immune cells, particularly in females. This response leads to more severe brain damage, including tau protein clumps, which are linked to Alzheimer’s disease progression.

Featured Neurology Neuroscience

·June 7, 2022·3 min read

Rapamycin Increases Alzheimer’s-Associated Plaques in Mice

Rapamycin, a drug approved for the treatment of cancer and transplant patients increases amyloid-beta protein plaques in the brains of mice.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·March 23, 2022·4 min read

How TREM2 Gene Mutation in Brain Microglia Immune Cells Can Increase Alzheimer’s Risk

A molecular process caused by the TREM2 gene mutation in the brain's microglia increases the risk of Alzheimer's disease, a new study reports.

Featured Genetics Neurology Neuroscience

·February 14, 2022·3 min read

How a Gene Variant Protects Against Alzheimer’s

The P522R gene variant increases expression levels of several microglia genes which are reduced in people with Alzheimer's disease.

Featured Genetics Neurology Neuroscience

·January 9, 2022·3 min read

Research Clears up How Brain ‘Cleaners’ Fail in ALS

Findings point to microglial TREM2 as a potential target for the treatment of ALS.

This shows single cell RNA sequencing of the microglia response in a mouse model of Alzheimer's

Featured Genetics Neurology Neuroscience

·December 1, 2021·4 min read

Targeting the Brain’s Immune Cells May Help Prevent Alzheimer’s Disease

A drug currently being tested in cancer clinical trials appears to prevent dysfunction in an immune cell signaling pathway associated with Alzheimer's disease. Blocking the pathway could prevent Alzheimer's from developing and slow the progression of symptoms for those who already have the disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·August 26, 2021·3 min read

Inflammatory Proteins Help Better Diagnose Progression of Alzheimer’s Disease

Testing for specific inflammatory proteins in cerebrospinal fluid can help doctors to diagnose the early onset of Alzheimer's disease and track the progression of the disease in patients.

Featured Genetics Neurology Neuroscience

·March 9, 2021·6 min read

CBD Reduces Plaque and Improves Cognition in Model of Familial Alzheimer’s

A two-week course of CBD helps normalize and restore the function of two proteins associated with reducing amyloid-beta accumulation in mouse models of familial Alzheimer's disease. CBD also reduces levels of IL-6, an immune protein associated with inflammation in Alzheimer's patients.