Researchers have discovered an early immune response in people with a genetic predisposition to Alzheimer's disease.
PLCG2-P522R, a genetic variant that protects against Alzheimer's disease, enhances key functions of immune cells.
Stimulating activation of microglia may help eliminate Alzheimer's associated plaques, thus helping to prevent the progression of the neurodegenerative disease.
Testing for specific inflammatory proteins in cerebrospinal fluid can help doctors to diagnose the early onset of Alzheimer's disease and track the progression of the disease in patients.
A drug currently being tested in cancer clinical trials appears to prevent dysfunction in an immune cell signaling pathway associated with Alzheimer's disease. Blocking the pathway could prevent Alzheimer's from developing and slow the progression of symptoms for those who already have the disease.
Two rare genetic variants on the NOTCH3 and TREM2 genes have been identified in some Alzheimer's patients.
Findings may help to shed light on how Alzheimer's and other neurodegenerative diseases develop.
Researchers uncover a second rare genetic mutation which increases the risk of developing Alzheimer's disease later in life.
Researchers report the TREM2 mutation can derail the immune cell's plaque-clearing activity.
Stimulating microglial cells could delay the onset of some neurodegenerative diseases, researchers report.
Carries of the TREM2 genetic mutation associated with Alzheimer's disease could develop the disease up to three years earlier than expected, a new study finds.
Findings could help in the development of treatments to prevent brain inflammation associated with Alzheimer's disease.
