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TREM2

This shows tyrobp expression in cells from the spinal cord in ALS

Featured Genetics Neurology Neuroscience

·April 7, 2019·5 min read

How ALS progresses on genetic and cellular level revealed by high-res spinal cord study

Changes in gene expression help researchers identify ALS associated pathways and establish the key drivers of motor neuron degeneration in the disease.

Featured Genetics Neurology Neuroscience

·July 11, 2019·4 min read

‘Crosstalk’ between genes promotes brain inflammation in Alzheimer’s

Findings could help in the development of treatments to prevent brain inflammation associated with Alzheimer's disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·August 26, 2021·3 min read

Inflammatory Proteins Help Better Diagnose Progression of Alzheimer’s Disease

Testing for specific inflammatory proteins in cerebrospinal fluid can help doctors to diagnose the early onset of Alzheimer's disease and track the progression of the disease in patients.

Featured Genetics Neurology Open Neuroscience Articles

·July 21, 2016·4 min read

Three Alzheimer’s Genetic Risk Factors Linked to Immune Cell Dysfunction

Researchers report the TREM2 mutation can derail the immune cell's plaque-clearing activity.

Featured Neurology Neuroscience

·October 19, 2018·5 min read

Regulating Microglial Activity May Reduce Inflammation in Neurodegenerative Diseases

Researchers report activating microglia may help reduce the imbalance between neuroprotection and neurotoxicity for neurodegenerative diseases.

Featured Neurology

·May 19, 2016·3 min read

Immune Cells May Protect Against Alzheimer’s

Researchers report microglia may actually protect the brain against Alzheimer's disease by containing the spread of amyloid plaques.

This is a histopathogic image of senile plaques seen in the cerebral cortex in a patient with presenile onset of Alzheimer disease.

Featured Genetics

·December 13, 2013·5 min read

New Gene Discovery Sheds More Light on Alzheimer’s Risk

Researchers uncover a second rare genetic mutation which increases the risk of developing Alzheimer's disease later in life.

Image shows a jigsaw in the shape of a head.

Featured Neurology Neuroscience

·May 30, 2017·5 min read

Phagocytes in the Brain: Good or Bad?

Stimulating microglial cells could delay the onset of some neurodegenerative diseases, researchers report.

Featured Genetics Neurology Neuroscience

·January 9, 2022·3 min read

Research Clears up How Brain ‘Cleaners’ Fail in ALS

Findings point to microglial TREM2 as a potential target for the treatment of ALS.

Featured Genetics Neuroscience Open Neuroscience Articles

·September 25, 2020·5 min read

A Genetic Variant That Protects Against Alzheimer’s Promotes Immune Cell Functions

PLCG2-P522R, a genetic variant that protects against Alzheimer's disease, enhances key functions of immune cells.

the image shows an MRI scan of an Alzheimer's patient who carries the TERM2 genetic mutation.

Featured Genetics

·October 18, 2013·3 min read

Genetic Mutation Linked to Alzheimer’s Disease Doubles Rate of Brain Tissue Loss

Carries of the TREM2 genetic mutation associated with Alzheimer's disease could develop the disease up to three years earlier than expected, a new study finds.