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Tau

·June 27, 2021·4 min read

Toxicity of Protein Involved in Alzheimer’s Triggered by a Chemical ‘Switch’

Study identifies specific chemical features of tau that may cause it to accumulate in the brain and trigger Alzheimer's disease.

Featured Genetics Neurology Neuroscience

·June 21, 2021·5 min read

Investigational Alzheimer’s Drug Improves Biomarkers of the Disease

Gantenerumab, an investigational drug for Alzheimer's disease, reduced amyloid plaques and lowered tau levels in the brains of people with genetic risk factors for the neurodegenerative disorder.

Featured Genetics Neurology Psychology

·June 17, 2021·3 min read

Depression and Tau Deposits Seen in Subset of Middle-Aged Persons

Depressed middle-aged carriers of the APOEe4 Alzheimer's genetic variant are at risk of developing tau accumulations in brain areas associated with emotion and memory.

Featured Neurology Neuroscience

·June 15, 2021·4 min read

New Treatment Stops Progression of Alzheimer’s Disease in Monkey Brains

Elderly monkeys treated with CpG ODN had 59% fewer deposits of Alzheimer's related plaques in their brains compared to those who did not receive the treatment. The treatment also helped improve cognitive function and slow the progression of Alzheimer's symptoms.

Featured Neurology Neuroscience

·June 14, 2021·3 min read

A New Model of Alzheimer’s Progression

A new model of Alzheimer's progression highlights the link between glial cells, toxic protein buildup, and neurodegeneration.

Featured Genetics Neurology Neuroscience

·May 19, 2021·6 min read

New Insight Into Protein Production in Brain Could Help Tackle Dementia

Researchers have identified a layer of genetic material involved in controlling the production of tau in the brain. The material is part of a larger family of non-coding genes that regulate and control other brain proteins associated with neurodegenerative disorders, such as Alzheimer's disease, Parkinson's, and PSP. The findings could lead to the development of new therapeutics to treat a range of neurodegenerative disorders.

Featured Neurology Neuroscience

·May 16, 2021·4 min read

Anesthetic May Affect Tau Spread in the Brain to Promote Alzheimer’s Disease Pathology

Sevoflurane, an anesthetic, causes tau to leave neurons and enter microglia. This stimulates the production of interleukin-6, leading to inflammation and cognitive impairment.

Featured Neurology Neuroscience

·May 5, 2021·3 min read

Does Eating a Mediterranean Diet Protect Against Memory Loss and Dementia?

Eating a Mediterranean-style diet can help protect the brain from tau protein build-up and brain shrinkage associated with Alzheimer's disease.

Featured Neurology Neuroscience

·April 29, 2021·5 min read

Alzheimer’s Disease Is Composed of Four Distinct Subtypes

Researchers have identified four distinct subtypes of Alzheimer's disease. The findings could lead to more individualized treatments for those with the neurodegenerative disorder.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 20, 2021·5 min read

Chaperone Protein Imbalance Promotes Toxic Tau Buildup in the Aging Brain

A new preclinical study has identified the role chaperone protein imbalance plays in initiating the accumulation of tau in the brain.

Featured Neurology Neuroscience

·April 12, 2021·5 min read

Imbalance in Gum Bacteria Linked to Alzheimer’s Disease Biomarker

An increase in bad gum bacteria and a decrease in good bacteria is associated with amyloid-beta in cerebral spinal fluid samples of older adults. The findings add to the growing body of evidence linking periodontal disease to the development of Alzheimer's.