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Tau

·January 6, 2023·4 min read

Inflammatory Trigger a New Clue in Alzheimer’s and PSP

An inflammatory trigger like one present during viral infections is elevated in those with Alzheimer's disease and progressive supranuclear palsy (PSP).

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·December 28, 2022·7 min read

New Biomarker Test Can Detect Alzheimer’s Neurodegeneration in Blood

A newly developed blood test can detect brain-derived tau (BD-tau), a biomarker of Alzheimer's disease neurodegeneration.

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·August 29, 2022·3 min read

Protein ‘Traffic Jam’ in Neurons Linked to Neurodegeneration

Dampening retromer activity slows down the trafficking of tau in neurodegenerative disorders, a new study reports.

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·August 11, 2022·6 min read

Researchers Explore the “Dark Side” of Alzheimer’s Disease Revealing New Biomarkers

A new collection of articles explores mapping brain overexcitability that underpins the dysregulation of vigilance, sleep-wake cycles, and validating effective biomarkers for Alzheimer's disease.

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·July 10, 2022·4 min read

Uncovering One of the Driving Forces of Alzheimer’s Disease

Study reveals how the Alzheimer's associated Tau protein changes from normal to a diseased state.

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·July 1, 2022·5 min read

Protecting the Brain From Dementia-Inducing Abnormal Protein Aggregates

Researchers reveal the critical role the p62 gene plays in the selective autophagy of tau oligomers.

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·June 3, 2022·5 min read

Overlooked Proteins May Be Key to Better Diagnosis of Alzheimer’s

Fragmented tau that accumulates in neurons in those with Alzheimer's disease may be a new target for drugs to treat the neurodegenerative disease.

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·April 20, 2022·5 min read

Single-Cell DNA Sequencing Offers a New Angle on the Causes of Alzheimer’s Disease

An abundance of newly acquired mutations in the mutations that occur at an accelerated speed is a telling pattern of Alzheimer's disease, researchers report.

This shows a depiction of a brain made up of rainbow colored lines

Featured Genetics Neurology Neuroscience

·April 13, 2022·5 min read

Novel Root Cause of Tau-Induced Neurodegeneration Discovered

mRNA decay may facilitate tau-induced damage to the brain and associated apoptosis that contributes to a range of neurodegenerative disorders. Researchers found the mechanism can be altered pharmacologically, providing a new target for the development of therapeutics to prevent or slow the progression of some neurodegenerative disorders.

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·April 4, 2022·7 min read

Loss of Neurons, Not Lack of Sleep, Makes Alzheimer’s Patients Drowsy

Degeneration of neurons associated with wakefulness, and not a lack of sleep, makes Alzheimer's patients more drowsy. The degeneration of these neurons is caused by the tau protein. In PSP, the damage to the neurons was associated with symptoms of sleep deprivation.

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·March 19, 2022·5 min read

New Strategy Reduces Brain Damage in PSP, Alzheimer’s, and Related Disorders in Mice

Alpha2-NKA, a protein that drives toxicity in astrocytes, was discovered in higher levels of brain samples from people who died of PSP, Alzheimer's and other tau-related neurodegenerative disorders. Treatment with an FDA-approved drug called digoxin may suppress the inflamed astrocytes and halt disease progression for those with tauopathy disorders.