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Tau

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Featured Genetics Neurology Neuroscience

·April 13, 2022·5 min read

Novel Root Cause of Tau-Induced Neurodegeneration Discovered

mRNA decay may facilitate tau-induced damage to the brain and associated apoptosis that contributes to a range of neurodegenerative disorders. Researchers found the mechanism can be altered pharmacologically, providing a new target for the development of therapeutics to prevent or slow the progression of some neurodegenerative disorders.

Featured Neurology Neuroscience

·April 4, 2022·7 min read

Loss of Neurons, Not Lack of Sleep, Makes Alzheimer’s Patients Drowsy

Degeneration of neurons associated with wakefulness, and not a lack of sleep, makes Alzheimer's patients more drowsy. The degeneration of these neurons is caused by the tau protein. In PSP, the damage to the neurons was associated with symptoms of sleep deprivation.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 19, 2022·5 min read

New Strategy Reduces Brain Damage in PSP, Alzheimer’s, and Related Disorders in Mice

Alpha2-NKA, a protein that drives toxicity in astrocytes, was discovered in higher levels of brain samples from people who died of PSP, Alzheimer's and other tau-related neurodegenerative disorders. Treatment with an FDA-approved drug called digoxin may suppress the inflamed astrocytes and halt disease progression for those with tauopathy disorders.

Featured Genetics Neurology Neuroscience

·February 2, 2022·4 min read

New Non-Mutated Protein Linked to Dementia

APOE proteins were enhanced in the brains of patients with dementia, even when they did not carry the Alzheimer's associated gene.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 9, 2022·4 min read

Findings Open the Way to More Precise Diagnoses and Treatments of Alzheimer’s Disease

Researchers have identified a link between misshapen, fast replicating tau proteins, and accelerated cognitive decline. The findings shed new light on the development and progression of Alzheimer's disease.

Featured Neurology Neuroscience

·December 11, 2021·5 min read

Malfunctioning Brain Cells a Potential Target for Alzheimer’s Treatment

Researchers have identified a rare population of potentially toxic senescent cells that may be a novel target for Alzheimer's disease therapies.

This shows two hands, a brain and neurons

Featured Neurology Neuroscience

·November 29, 2021·4 min read

Potential Cause of Alzheimer’s Discovered

The form in which isomers take can increase the risk of developing dementia, researchers report. Drugs in development to improve autophagy may help prevents Alzheimer's from developing.

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Featured Neurology Neuroscience

·November 27, 2021·5 min read

New Framework for Analyzing Alzheimer’s Disease Identifies Not One Form, but Three

A new framework reveals Alzheimer's disease is far more complex than previously believed. Rather than being a disease where the same causes produce the same outcomes, researchers found three different models for the disease, each with its own characterizations and dynamics.

Featured Neurology Neuroscience

·November 6, 2021·5 min read

Sleeping Longer Than 6.5 Hours a Night Associated With Cognitive Decline

Older adults who sleep less than 4.5 hours, or more than 6.5 hours per night and who experience sleep disruptions are at greater risk of cognitive decline, researchers report.

This is an illustration of neurons, amyloid plaques and tau

Featured Neurology Neuroscience

·October 29, 2021·4 min read

Key Alzheimer’s Feature Eliminated in Animal Model

Inhibiting the NHE6 gene abolished the formation of amyloid-beta plaques in mouse models of Alzheimer's disease.

Featured Neurology Neuroscience

·October 29, 2021·4 min read

Cause of Alzheimer’s Progression in the Brain Identified

New findings contradict the existing thought that Alzheimer's starts from a single point in the brain and causes a chain reaction that leads to cell death. Instead, a new study reports, Alzheimer's disease reaches different brain regions early on. The speed by which the disease kills brain cells in these regions directly impacts the progression of Alzheimer's.