Study in mice and humans reveals reinforcing the activity of microglia could slow, or potentially halt, the proliferation of Tau tangles in Alzheimer's disease. Read More
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Women with the ApoE e4 genetic risk factor for Alzheimer's are more susceptible to tau accumulation in the brain than men. Read More
Your sleep history during middle age may predict Alzheimer's pathology later in life. A decrease in sleep quality between 50 and 70 years of age is associated with higher levels of tau and amyloid beta in the brain. Changes in brain activity and quality of sleep could be a biomarker for Alzheimer's disease. Read More
During early Alzheimer's disease, SOD1 initially weakens levels of Tau protein. However, as the disease progresses, the antioxidant becomes less effective at protecting the brain against neurodegeneration. Read More
Researchers have engineered a vaccine using virus-like particles that target Tau tangles in mouse models of Alzheimer's disease. Following the administration of the vaccine, the mice developed antibodies that cleared tau proteins, with the response lasting for a month. The mice also showed improvements in memory based tests and had less brain shrinkage than their peers who did not receive the vaccine. This suggests the vaccine prevented apoptosis. Researchers hope to move the vaccine to human clinical trials in the future. Read More
Researchers have identified average levels of biological and anatomical brain changes associated with Alzheimer's disease over thirty years before symptoms appear. In those with genetic risk factors for Alzheimer's, researchers found changes in cognitive performance up to 15 years before becoming symptomatic. Changes in Tau levels in the cerebral spinal fluid appeared up to 34 years before dementia symptoms occurred, and physical changes to the medial temporal lobe were apparent up to 9 years before cognitive impairment was apparent. Read More
Inducing gamma oscillations with visual stimulation via a process known as gamma entrainment using sensory stimuli, or GENUS, was shown to reduce amyloid plaques and phosphorylated tau in mouse models of dementia. Providing GENUS daily during the early stages of neurodegeneration helps preserve neural and synaptic density across multiple brain areas and improves cognitive performance for learning and spatial memory tasks. Read More
A new two-tier diagnostic blood test which evaluates both amyloid beta and tau, can help detect Alzheimer's disease in presymptomatic patients. Read More
Self-propagating amyloid and tau act as prions in the pathology of Alzheimer's disease. Higher levels of the prions in human brain samples were strongly correlated with early onset of Alzheimer's and death at a younger age. Read More
PET imaging of former NFL players who exhibited cognitive decline and psychiatric symptoms linked to CTE showed higher levels of tau in areas of the brain associated with the neurodegenerative disease. Read More
Study reinforces and explains the links between sleep deprivation and neurodegenerative diseases, researchers say. Read More
Researchers report they have identified biomarkers of Alzheimer's disease in spinal fluid samples of a significant number of older patients hospitalized as a result of hip fractures. The study suggests neural alterations that lead to poor balance in older people may signify an increased risk of falls that result in hip fractures, and Alzheimer's disease. Researchers suggest the hip fracture, therefore, may serve as an early sign of Alzheimer's in older patients. Read More
