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oligodendrocytes

Autism Featured Genetics Neuroscience

·February 3, 2020·4 min read

New study links autism to specific cell

Postmortem study reveals those with ASD have cellular abnormalities that impair the production of myelin.

This shows a dna strand made into the shape of a human body

Electrophysiology Featured Genetics Neurology Neuroscience

·January 12, 2020·4 min read

A molecular switch for repairing central nervous system disorders

A global knockout of the thrombin receptor PAR1 accelerates myelin development. The findings could help with the development of treatments for diseases associated with demyelination, like multiple sclerosis.

Featured Genetics Neurology Neuroscience

·October 7, 2019·3 min read

Surprise contributor to multiple sclerosis identified

Oligodendrocyte progenitor cells (OPCs) actively contribute to neuroinflammation associated with multiple sclerosis.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·August 21, 2019·4 min read

‘Key player’ identified in genetic link to psychiatric conditions

CYFIP1 plays a key role in the damaging effects of 15q11.2 deletion. When CYFIP1 is missing, myelin abnormalities occur. The findings shed light on how psychiatric disorders, such as schizophrenia and autism, may develop.

Featured Neuroscience Open Neuroscience Articles Psychology

·August 13, 2019·4 min read

Glial cells are critical players in brain’s response to social stress

The behavior of oligodendrocytes plays a critical role in determining whether we tolerate or succumb to stress.

Featured Genetics Neurology Neuroscience

·May 1, 2019·5 min read

Restoring brain function in mice with symptoms of Alzheimer’s disease

Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.

oligodendrocytes from alzheimer's brain tissue are shown

Featured Genetics Neurology Neuroscience

·May 1, 2019·6 min read

A comprehensive map of how Alzheimer’s affects the brain

Axon myelination is significantly disrupted in patients with Alzheimer's disease. Researchers also found brain cells of men and women vary significantly in how their genes respond to the neurodegenerative disease.

Featured Genetics Neuroscience Psychology

·April 24, 2019·4 min read

Hypersociability in Williams syndrome result of Myelination deficits

Myelin thickness and oligodendrocytes were significantly reduced in the prefrontal cortex in mouse models of Williams syndrome.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 18, 2019·5 min read

Study shows promise in repairing damaged myelin

A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.

Brain Cancer Featured Genetics Neurology Neuroscience

·April 11, 2019·4 min read

Shutting down deadly pediatric brain cancer at its earliest moments

Dysregulation of Zfp36l1 causes neural lineage progenitor cells to grow rapidly, taking on the properties of fast growing stem cells as they become cancerous.

Featured Genetics Neurology Neuroscience

·January 29, 2019·5 min read

Researchers Generate and Track Development of Myelin Producing Brain Cells

Researchers have successfully created stem cell derived brain cells which can generate oligodendrocytes, neurons and astrocytes.

Featured Genetics Neurology Neuroscience

·January 23, 2019·5 min read

Shedding Light on Brain Cell Changes in Multiple Sclerosis

A new study sheds light on brain cells implicated in multiple sclerosis. Researchers found there are several types of oligodendrocytes, and the ratio of these cells differ significantly in those with MS. The findings could help develop new targeted treatments for progressive multiple sclerosis.