Surprise contributor to multiple sclerosis identified
Oligodendrocyte progenitor cells (OPCs) actively contribute to neuroinflammation associated with multiple sclerosis.... Read More...
oligodendrocytes
‘Key player’ identified in genetic link to psychiatric conditions
CYFIP1 plays a key role in the damaging effects of 15q11.2 deletion. When CYFIP1 is missing, myelin abnormalities occur. The findings shed light on how psychiatric disorders, such as schizophrenia and autism, may develop.... Read More...
Glial cells are critical players in brain’s response to social stress
The behavior of oligodendrocytes plays a critical role in determining whether we tolerate or succumb to stress. ... Read More...
Restoring brain function in mice with symptoms of Alzheimer’s disease
Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.... Read More...
A comprehensive map of how Alzheimer’s affects the brain
Axon myelination is significantly disrupted in patients with Alzheimer's disease. Researchers also found brain cells of men and women vary significantly in how their genes respond to the neurodegenerative disease.... Read More...
Hypersociability in Williams syndrome result of Myelination deficits
Myelin thickness and oligodendrocytes were significantly reduced in the prefrontal cortex in mouse models of Williams syndrome. ... Read More...
Study shows promise in repairing damaged myelin
A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.... Read More...
Shutting down deadly pediatric brain cancer at its earliest moments
Dysregulation of Zfp36l1 causes neural lineage progenitor cells to grow rapidly, taking on the properties of fast growing stem cells as they become cancerous.... Read More...
Researchers Generate and Track Development of Myelin Producing Brain Cells
Researchers have successfully created stem cell derived brain cells which can generate oligodendrocytes, neurons and astrocytes. ... Read More...
Shedding Light on Brain Cell Changes in Multiple Sclerosis
A new study sheds light on brain cells implicated in multiple sclerosis. Researchers found there are several types of oligodendrocytes, and the ratio of these cells differ significantly in those with MS. The findings could help develop new targeted treatments for progressive multiple sclerosis.... Read More...
Helping Cells to Help Themselves May Benefit Multiple Sclerosis
Researchers have discovered how the body is able to initiate repair mechanisms which can limit the extent of damage to the myelin sheath. The findings could help with the development of new therapies for multiple sclerosis.... Read More...
New Insight Into the Process of New Neuron Generation in the Adult Brain
Researchers discover the protein nestin produced in astrocytes plays a role in inhibiting neural differentiation. The study reports nestin does not control adult neurogenesis by acting within neural stem cells, but by regulating Notch signals neural stem cells receive from astrocytes. ... Read More...