FeaturedGeneticsNeurologyNeuroscience·May 19, 2020Animal study shows human brain cells repair damage in multiple sclerosisHuman iPSCs transplanted into animal models of multiple sclerosis help repair cell damage and restore function. Read More
FeaturedGeneticsNeurologyNeuroscience·April 27, 2020More evidence Parkinson’s disease may start in the gutEnteric neurons appear to play a key role in the development of Parkinson's disease. The findings support the hypothesis and previous studies that the neurodegenerative disease may start in the gut before spreading to the brain. Researchers also found oligodendrocytes were affected during the early stages of Parkinson's, even before the loss of dopaminergic neurons. Read More
AutismFeaturedGeneticsNeuroscience·February 3, 2020New study links autism to specific cellPostmortem study reveals those with ASD have cellular abnormalities that impair the production of myelin. Read More
ElectrophysiologyFeaturedGeneticsNeurologyNeuroscience·January 12, 2020A molecular switch for repairing central nervous system disordersA global knockout of the thrombin receptor PAR1 accelerates myelin development. The findings could help with the development of treatments for diseases associated with demyelination, like multiple sclerosis. Read More
FeaturedGeneticsNeurologyNeuroscience·October 7, 2019Surprise contributor to multiple sclerosis identifiedOligodendrocyte progenitor cells (OPCs) actively contribute to neuroinflammation associated with multiple sclerosis. Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience ArticlesPsychology·August 21, 2019‘Key player’ identified in genetic link to psychiatric conditionsCYFIP1 plays a key role in the damaging effects of 15q11.2 deletion. When CYFIP1 is missing, myelin abnormalities occur. The findings shed light on how psychiatric disorders, such as schizophrenia and autism, may develop. Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·August 13, 2019Glial cells are critical players in brain’s response to social stressThe behavior of oligodendrocytes plays a critical role in determining whether we tolerate or succumb to stress. Read More
FeaturedGeneticsNeurologyNeuroscience·May 1, 2019Restoring brain function in mice with symptoms of Alzheimer’s diseaseSenolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition. Read More
artificial intelligencedeep learningFeaturedGeneticsmachine learningNeurologyNeuroscienceneurotech·May 1, 2019A comprehensive map of how Alzheimer’s affects the brainAxon myelination is significantly disrupted in patients with Alzheimer's disease. Researchers also found brain cells of men and women vary significantly in how their genes respond to the neurodegenerative disease. Read More
FeaturedGeneticsNeurosciencePsychology·April 24, 2019Hypersociability in Williams syndrome result of Myelination deficitsMyelin thickness and oligodendrocytes were significantly reduced in the prefrontal cortex in mouse models of Williams syndrome. Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·April 18, 2019Study shows promise in repairing damaged myelinA study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS. Read More
Brain CancerFeaturedGeneticsNeurologyNeuroscience·April 11, 2019Shutting down deadly pediatric brain cancer at its earliest momentsDysregulation of Zfp36l1 causes neural lineage progenitor cells to grow rapidly, taking on the properties of fast growing stem cells as they become cancerous. Read More
