FeaturedNeurologyNeuroscience·June 2, 2021·8 min readHow HIV Infection Shrinks the Brain’s White MatterHIV infection prevents myelin-associated oligodendrocytes from maturing, this, in turn, hampers white matter production in the brain.Read More
FeaturedNeurologyNeuroscience·March 9, 2021·5 min readMyelin Loss Is a Major Factor in Age-Related Brain DeteriorationCells that drive myelin repair become less efficient due to aging. Myelin loss results in cognitive decline and is central to a number of neurodegenerative diseases.Read More
FeaturedGeneticsNeurologyNeuroscience·May 19, 2020·2 min readAnimal study shows human brain cells repair damage in multiple sclerosisHuman iPSCs transplanted into animal models of multiple sclerosis help repair cell damage and restore function.Read More
FeaturedGeneticsNeurologyNeuroscience·April 27, 2020·3 min readMore evidence Parkinson’s disease may start in the gutEnteric neurons appear to play a key role in the development of Parkinson's disease. The findings support the hypothesis and previous studies that the neurodegenerative disease may start in the gut before spreading to the brain. Researchers also found oligodendrocytes were affected during the early stages of Parkinson's, even before the loss of dopaminergic neurons.Read More
AutismFeaturedGeneticsNeuroscience·February 3, 2020·4 min readNew study links autism to specific cellPostmortem study reveals those with ASD have cellular abnormalities that impair the production of myelin.Read More
ElectrophysiologyFeaturedGeneticsNeurologyNeuroscience·January 12, 2020·4 min readA molecular switch for repairing central nervous system disordersA global knockout of the thrombin receptor PAR1 accelerates myelin development. The findings could help with the development of treatments for diseases associated with demyelination, like multiple sclerosis.Read More
FeaturedGeneticsNeurologyNeuroscience·October 7, 2019·3 min readSurprise contributor to multiple sclerosis identifiedOligodendrocyte progenitor cells (OPCs) actively contribute to neuroinflammation associated with multiple sclerosis.Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience ArticlesPsychology·August 21, 2019·4 min read‘Key player’ identified in genetic link to psychiatric conditionsCYFIP1 plays a key role in the damaging effects of 15q11.2 deletion. When CYFIP1 is missing, myelin abnormalities occur. The findings shed light on how psychiatric disorders, such as schizophrenia and autism, may develop.Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·August 13, 2019·4 min readGlial cells are critical players in brain’s response to social stressThe behavior of oligodendrocytes plays a critical role in determining whether we tolerate or succumb to stress.Read More
FeaturedGeneticsNeurologyNeuroscience·May 1, 2019·5 min readRestoring brain function in mice with symptoms of Alzheimer’s diseaseSenolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.Read More
FeaturedGeneticsNeurologyNeuroscience·May 1, 2019·6 min readA comprehensive map of how Alzheimer’s affects the brainAxon myelination is significantly disrupted in patients with Alzheimer's disease. Researchers also found brain cells of men and women vary significantly in how their genes respond to the neurodegenerative disease.Read More
FeaturedGeneticsNeurosciencePsychology·April 24, 2019·4 min readHypersociability in Williams syndrome result of Myelination deficitsMyelin thickness and oligodendrocytes were significantly reduced in the prefrontal cortex in mouse models of Williams syndrome.Read More
