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neuropsychopharmacology

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·June 25, 2019·4 min read

Common antidepressants interact with opioid med to lessen pain relief

SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.

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·June 10, 2019·4 min read

Safe to breastfeed while on bipolar meds? Jury’s still out

Previous research into the effects of lithium exposure via breastmilk are poorly designed and sparse, researchers report. Until more research is done, mothers and babies should be reviewed on a case-by-case basis for lithium continuation, as discontinuing the medication could pose a significant risk for both child and parent.

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·June 3, 2019·3 min read

Diabetes drug alleviates anxiety in mice

Metformin, a common diabetes medication, shows promise for the treatment of anxiety and depression.

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·May 30, 2019·4 min read

‘Ecstasy’ shows promise for post-traumatic stress treatment

MDMA shows promise for the treatment of post-traumatic stress disorder. Combining the use of Ecstasy with psychotherapy treatments resulted in a reduction of PTSD symptoms after just one session. 54% of the study participants no longer met the PTSD criteria after two sessions. Patients also reported improvements in depression symptoms.

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·May 21, 2019·5 min read

Study supports effectiveness of new fast-acting antidepressant, esketamine nasal spray

Esketamine combined with antidepressants acts rapidly to help alleviate symptoms in those with treatment-resistant depression.

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·May 16, 2019·5 min read

Ketamine: The illicit party psychedelic that promises to heal depression

Ketamine, an anesthetics which has been commonly used as an illicit party drug, is helping people overcome depression. The drug works rapidly and provides lasting relief from depressive symptoms for weeks after exposure. Researchers are examining how ketamine works in the brain to help positively influence behavior in those with mood disorders.

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·April 24, 2019·4 min read

CBD reduces impairment caused by cannabis

Cannabidiol may buffer the effects of THC on the brain for those who use marijuana. Marijuana with a higher CBD content restores disruptions to the salience network caused by THC exposure.

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·April 23, 2019·2 min read

Texas A&M Research Leads To First Drug For Postpartum Depression

A newly developed drug can help combat the effects of postnatal depression.

This shows how NV-5138 affects dendrites

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·April 17, 2019·3 min read

New drug mimics benefits of ketamine for depression

NV-5138, a small molecule drug that mimics the action of ketamine, provides fast-acting antidepressant responses in rodent models of depression. The drug is currently undergoing Phase 1 testing in humans.

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·April 4, 2019·5 min read

Psychedelic drug MDMA may reawaken ‘critical period’ in brain to help treat PTSD

MDMA, a psychedelic drug, has successfully been used to reopen the 'critical period' of learning the reward values of social behaviors. Researchers report, in mature mice given MDMA, oxytocin triggers signaling in synapses that help encode social learning and memory, a process that does not usually occur in older animals. The findings could help in the development of treatments for PTSD and other disorders.