Results of a new study offer compelling evidence for the first time that mephedrone, like cocaine, does have potential for abuse and addiction. “The effects of mephedrone on the brain’s reward circuits are comparable to similar doses of cocaine,” Dr. Malanga, a professor of neurology, pediatrics and psychology at UNC School of Medicine said. “As expected our research shows that mephedrone likely has significant abuse liability.”
Research provides the first evidence that mechanisms regulated by the Runx1 gene control the balance between the surveillant versus activated microglia states.
Researchers have identified an exceptional mouse model of schizophrenia. The study identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia.
A new study funded by the NIMH suggests GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the negative side effects of the well known street drug.
A synthetic compound, decynium-22, is able to turn off SERT in the brain, enhancing the effectiveness of SSRIs.
Researchers suggest serotonin metabolism in the pineal gland could play a role in the underlying cause of depression. The findings were based on biochemical changes which were seen to be in association with improvements in depression.
Topiramate, a drug used to treat migraine headaches and epilepsy, could also help treat cocaine addiction, a new study reports.
A new study reports psilocybin influences the amygdala, weakening the processing of negative stimuli. Researchers hope the finding could pave the way for new treatment approaches for some psychiatric disorders.
Researchers report administering cannabinoids soon after a traumatic event can prevent PTSD-like symptoms in rats.
Researchers establish a link between short term exposure to lithium and potential kidney damage.