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neuropsychopharmacology

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·December 2, 2022·4 min read

How Ketamine Acts as a ‘Switch’ in the Brain

Ketamine alters neural activity in the cerebral cortex, silencing normally active neurons and activating neurons that are normally inactive. The ketamine activity-induced "switch" in brain regions associated with depression may help explain its treatment effects.

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·March 16, 2018·4 min read

Study Casts Doubt on Ketamine Nasal Sprays for Depression

A new study reports intranasal delivery of ketamine may cause problematic side effects for some people with depression.

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·September 11, 2018·4 min read

Inhaled Version of Blood Pressure Drug May Help Reduce Anxiety

Amiloride, a common blood pressure medication, shows potential in treating anxiety disorder and pain when administered in nebulized form, researchers report.

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·March 5, 2021·3 min read

Anti-Hyperlipidemia Drug Improves Brain Connectivity Schizophrenia

Fenofibrate, a drug developed to control cholesterol, alleviated brain and behavioral abnormalities in mouse models of schizophrenia.

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·April 23, 2022·4 min read

Fetal Exposure to Antidepressants May Affect Infants’ Brain Development

Fetal exposure to antidepressants or antiepileptic medications may affect the development of newborn brain networks.

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·June 22, 2018·4 min read

Ketamine Acts Fast to Treat Depression and Its Effects Last, But How?

Researchers explore the mechanisms behind ketamine's effectiveness at treating depression. The study reports the long lasting effects of ketamine may be due to G proteins timing in moving back to lipid rafts.

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·February 21, 2021·4 min read

From Trippy Drugs to Therapeutic Aids – How Psychedelics Got Their Groove Back

From microdosing to improve cognition, to treating a range of mental health disorders, researchers evaluate the rise in the use of psychedelics and their potential as medicines.

The image show a a drawing of a cannabis sativa plant.

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·September 5, 2014·3 min read

Cannabis Prevents the Negative Behavioral and Physiological Effects PTSD

Researchers report administering cannabinoids soon after a traumatic event can prevent PTSD-like symptoms in rats.

Image shows how MDMA binds to serotonin transporters.

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·July 14, 2016·3 min read

Why Scientists are Calling for Experiments on Ecstasy

Researchers call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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·May 3, 2021·4 min read

Same Drug Can Have Opposite Effects on Memory Depending on Sex

Osanetant, a drug that inhibits the Tac2 pathway, has opposite effects on the recall of traumatic events in male and female mice.

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·June 25, 2019·4 min read

Common antidepressants interact with opioid med to lessen pain relief

SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.