Previous research into the effects of lithium exposure via breastmilk are poorly designed and sparse, researchers report. Until more research is done, mothers and babies should be reviewed on a case-by-case basis for lithium continuation, as discontinuing the medication could pose a significant risk for both child and parent.
MDMA shows promise for the treatment of post-traumatic stress disorder. Combining the use of Ecstasy with psychotherapy treatments resulted in a reduction of PTSD symptoms after just one session. 54% of the study participants no longer met the PTSD criteria after two sessions. Patients also reported improvements in depression symptoms.
Ketamine, an anesthetics which has been commonly used as an illicit party drug, is helping people overcome depression. The drug works rapidly and provides lasting relief from depressive symptoms for weeks after exposure. Researchers are examining how ketamine works in the brain to help positively influence behavior in those with mood disorders.
A newly developed drug can help combat the effects of postnatal depression.
NV-5138, a small molecule drug that mimics the action of ketamine, provides fast-acting antidepressant responses in rodent models of depression. The drug is currently undergoing Phase 1 testing in humans.
MDMA, a psychedelic drug, has successfully been used to reopen the 'critical period' of learning the reward values of social behaviors. Researchers report, in mature mice given MDMA, oxytocin triggers signaling in synapses that help encode social learning and memory, a process that does not usually occur in older animals. The findings could help in the development of treatments for PTSD and other disorders.
The mGlu2 receptor plays a critical role in the effectiveness of ketamine for treating depression.
A new study reports those who microdose psychedelics report improvements in attention and mental health. However, a number of people report an increase in neuroticism following six weeks of microdosing.