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neuropsychopharmacology

·March 6, 2022·2 min read

How Long-Term Benzodiazepine Use Leads to Cognitive Impairments

Mouse study reveals synaptic loss associated with a daily sleep-inducing dose of diazepam for several weeks leads to cognitive impairments. However, the effect was reversible after discontinuing benzodiazepine use.

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·November 19, 2021·5 min read

Psychedelics Show Promise in Treating Mental Illness

A growing body of evidence suggests psychedelics including psilocybin and LSD show promise in providing lasting relief from symptoms for those suffering some mental health disorders. Researchers found DOI, a similar drug to LSD, reduced negative behavioral responses following fear triggers in mouse models of anxiety.

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·October 22, 2021·4 min read

Common Antidepressant Should No Longer Be Used to Treat People With Dementia

Mirtazapine, an antidepressant commonly prescribed to treat dementia-associated agitation, is no more effective than a placebo and may increase mortality risks, researchers report.

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·October 14, 2021·4 min read

Brain Activity Fluctuations May Hold the Keys to Psychiatric Treatment Efficacy

Moment-to-moment fluctuations in brain activity over a three-minute period can reliably predict how receptive a person with social anxiety will be to cognitive behavioral therapy.

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·July 25, 2021·4 min read

The Future of Psychedelic Science

From treating depression and other mental health disorders, to helping relieve chronic pain, researchers discuss the advantages and implications of psychedelic treatments.

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·July 7, 2021·4 min read

Work Like a Dream: New Anticholinergic Drug Keeps PTSD Flashbacks and Nightmares Away

Trihexyphenidyl, an anticholinergic medication commonly prescribed for Parkinson's symptoms, appears to alleviate negative memory flashbacks and nightmares experienced by those with PTSD.

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·May 3, 2021·4 min read

Same Drug Can Have Opposite Effects on Memory Depending on Sex

Osanetant, a drug that inhibits the Tac2 pathway, has opposite effects on the recall of traumatic events in male and female mice.

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·April 6, 2021·4 min read

Resurging Psychedelic Therapies for Depression

As interest in using psychedelics to treat a range of mental health disorders grows, researchers consider the impact and therapeutic benefits of using psychedelics to help alleviate symptoms of depression.

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·March 5, 2021·3 min read

Anti-Hyperlipidemia Drug Improves Brain Connectivity Schizophrenia

Fenofibrate, a drug developed to control cholesterol, alleviated brain and behavioral abnormalities in mouse models of schizophrenia.

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·March 3, 2021·6 min read

Researchers Identify Brain Ion Channel as New Approach to Treating Depression

Ezogabine, a drug that opens up the KCNQ2/3 type potassium channel, significantly improved symptoms of depression and anhedonia.

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·February 21, 2021·4 min read

From Trippy Drugs to Therapeutic Aids – How Psychedelics Got Their Groove Back

From microdosing to improve cognition, to treating a range of mental health disorders, researchers evaluate the rise in the use of psychedelics and their potential as medicines.

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·February 18, 2021·4 min read

New Information on the Effects of Antidepressants

SSRI's, ketamine, and tricyclic antidepressants all bind with TrkB. The findings challenge the roles serotonin and glutamate receptors play in the effects of antidepressant medications.