Psychedelics, such as psilocybin, provide lasting improvements in mood and feelings of social connectedness, after the effect of the drug has worn off.
Backing up previous research, a new study reveals psychedelics can have beneficial effects for treating PTSD when combined with traditional trauma-focused psychotherapy. Findings suggest MDMA assisted therapy is significantly more effective at treating patients with persistent PTSD than psychotherapy alone.
Researchers have distinguished two different molecular pathways responsible for addiction and the prosocial feelings generated by MDMA. The findings could lead to novel treatments for psychiatric disorders marked by withdrawal and social awkwardness.
Sertraline (Zoloft), a commonly prescribed SSRI antidepressant, may not be as effective at treating depression within 6 weeks as previously thought. However, the drug is effective for treating anxiety symptoms.
Numerous studies have linked controlled psychedelics to improvements in mental health conditions such as depression and PTSD. In March, the FDA approved Esketamine as a treatment for depression. However, with much stigma surrounding psychedelics, researchers question how many patients would take psychedelic medications if prescribed to them. According to a new study, 40% of people with no experience of psychedelics would be unlikely to take the prescription due to fears of 'brain damage' or a 'bad trip'.
A new study clarifies the mechanism behind how ketamine works as an antidepressant. Researchers say there is evidence to suggest ketamine binds to NMDA receptors, instead of opioid receptors. Reducing the belief that ketamine is an opioid may make patients with depression more open to using the treatment.
SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.
Previous research into the effects of lithium exposure via breastmilk are poorly designed and sparse, researchers report. Until more research is done, mothers and babies should be reviewed on a case-by-case basis for lithium continuation, as discontinuing the medication could pose a significant risk for both child and parent.
MDMA shows promise for the treatment of post-traumatic stress disorder. Combining the use of Ecstasy with psychotherapy treatments resulted in a reduction of PTSD symptoms after just one session. 54% of the study participants no longer met the PTSD criteria after two sessions. Patients also reported improvements in depression symptoms.
Ketamine, an anesthetics which has been commonly used as an illicit party drug, is helping people overcome depression. The drug works rapidly and provides lasting relief from depressive symptoms for weeks after exposure. Researchers are examining how ketamine works in the brain to help positively influence behavior in those with mood disorders.