After inserting a gene into mice that increases choline transporter and as a result increases acetylcholine at the neuromuscular junctions, the engineered mice were able to run on treadmills twice as long as controls without the inserted gene.
The removal of a certain class of potassium channels from the surface of nociceptors is believed to be a key factor in inflammatory pain signaling. Using gene interference to reduce the expression of these specific potassium channels on nociceptors, researchers were able to produce hyperexcitability in nociceptors resembling that seen in inflammatory pain signaling.
Fragile X Tremor Ataxia Syndrome (FXTAS) research shows that inhibiting histone acetylation could help control expression of toxic mRNA. FXTAS symptoms are mainly caused by overproduction of toxic mRNA, making this research very important for researchers working with FXTAS.
Neurobiologists have genetically engineered mice to smell light. This optogenetics research provides a better understanding of the neural basis of...
New research points to a DNA sequence that causes the DUX4 gene to become more active in producing proteins that are toxic to muscle cells, leading to a form of muscular dystrophy.