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hippocampus

·April 11, 2023·4 min read

Scientists Enhance New Neurons to Restore Memory and Elevate Mood in Alzheimer’s Disease

Stimulating the Supramammilary nucleus in the hypothalamus enhanced adult-born neurons in the hippocampus of mouse models of Alzheimer's disease. These modified adult-born neurons restored both cognitive impairments and mood-related disorders associated with Alzheimer's in the mice.

Electrophysiology Featured Neuroscience

·April 11, 2023·2 min read

Key Memory Receptors Are Located on Interneurons

Interneural α5-GABAARs play a critical physiological role in promoting spatial learning and serve as essential targets for the modulation of contextual memory.

Featured Neurology Neuroscience

·April 6, 2023·4 min read

Activating Adult-Born Neurons Through Deep Brain Stimulation Alleviates Alzheimer’s Symptoms

Deep brain stimulation of newborn hippocampal neurons restored both cognitive and non-cognitive function in mouse models of Alzheimer's disease.

Featured Genetics Neuroscience

·April 2, 2023·4 min read

A Key Process in How the Brain Consolidates Memories

Researchers have identified a molecular process involved in gene expression in neurons which appears to play a key role in memory consolidation.

This shows the brain model of the hippocampus

Featured Neuroscience

·March 24, 2023·3 min read

A New Full-Scale 3D Structural Model of the Human Hippocampus

Researchers have developed a new 3D, high-resolution model of the CA1 area of the human hippocampus.

Featured Neuroscience Open Neuroscience Articles Psychology

·March 15, 2023·3 min read

Characterizing Abnormal Neural Networks in Dogs With Anxiety

Dogs with anxiety have stronger neural connections between the amygdala and other areas of the anxiety network in the brain compared to less anxious dogs.

Featured Neuroscience Open Neuroscience Articles

·March 15, 2023·3 min read

Memories Could Be Lost if Two Key Brain Regions Fail to Sync Together

If neural assemblies between the hippocampus and prefrontal cortex fail to sync together at the correct time, memories are lost.

Featured Genetics Neuroscience

·March 8, 2023·4 min read

How Gene Expression Controls Synaptic Plasticity in the Aging Human Brain

M1 muscarinic acetylcholine receptor (mAChR) dependent LTP and LTD share a common AMPA trafficking pathway. Either the upregulation of neurotransmitter receptor genes or suppression of the downregulation could improve synaptic dysfunction associated with age-related neurodegeneration. The findings could assist in the creation of new therapies for Alzheimer's disease that target synaptic plasticity.

Featured Neuroscience

·February 28, 2023·3 min read

Studying Brain Oscillations to Understand What Makes a Memory Stick

Memory formation requires higher-frequency ripples in the hippocampus and lower-frequency ripples in the parietal cortex. However, to make a memory stick, coordinated high-frequency ripples between the hippocampus and parietal cortex are required.

Featured Neuroscience

·February 14, 2023·6 min read

Mysterious Brain Activity in Mice Watching a Movie Could Help Tackle Alzheimer’s and Improve AI

Tracking hippocampal neurons in mice as they watched a movie revealed novel ways to improve artificial intelligence and track neurological disorders associated with memory and learning deficits.

Featured Neuroscience

·February 14, 2023·4 min read

Social Isolation Triggers Astrocyte-Mediated Deficits in Learning and Memory

During periods of social isolation, astrocytes in the brain become hyperactive. This suppresses circuit formation and memory formation. Reversing astrocyte hyperactivity can help mitigate memory deficits associated with social isolation.

Featured Neurology Neuroscience

·February 13, 2023·5 min read

Study Reveals How CBD Counters Epileptic Seizures

Cannabidiol, or CBD, blocks the ability of lysophosphatidylinositol (LPI) to amplify neural signals in the hippocampus. LPI weakens the signals that counter seizures, further explaining the value of CBD to treat epilepsy.